A history of Chagas disease transmission, control, and re-emergence in peri-rural La Joya, Peru

Stephen Delgado, Ricardo Castillo Neyra, Víctor R Quispe Machaca, Jenny Ancca Juárez, Lily Chou Chu, Manuela Renee Verastegui, Giovanna M Moscoso Apaza, César D. Bocángel, Aaron W. Tustin, Charles R Sterling, Andrew Comrie, César Náquira, Juan G Cornejo del Carpio, Robert H. Gilman, Caryn Bern, Michael Z. Levy

Research output: Chapter in Book/Report/Conference proceedingChapter

25 Citations (Scopus)

Abstract

Background:The history of Chagas disease control in Peru and many other nations is marked by scattered and poorly documented vector control campaigns. The complexities of human migration and sporadic control campaigns complicate evaluation of the burden of Chagas disease and dynamics of Trypanosoma cruzi transmission.Methodology/Principal Findings:We conducted a cross-sectional serological and entomological study to evaluate temporal and spatial patterns of T. cruzi transmission in a peri-rural region of La Joya, Peru. We use a multivariate catalytic model and Bayesian methods to estimate incidence of infection over time and thereby elucidate the complex history of transmission in the area. Of 1,333 study participants, 101 (7.6%; 95% CI: 6.2-9.0%) were confirmed T. cruzi seropositive. Spatial clustering of parasitic infection was found in vector insects, but not in human cases. Expanded catalytic models suggest that transmission was interrupted in the study area in 1996 (95% credible interval: 1991-2000), with a resultant decline in the average annual incidence of infection from 0.9% (95% credible interval: 0.6-1.3%) to 0.1% (95% credible interval: 0.005-0.3%). Through a search of archival newspaper reports, we uncovered documentation of a 1995 vector control campaign, and thereby independently validated the model estimates.Conclusions/Significance:High levels of T. cruzi transmission had been ongoing in peri-rural La Joya prior to interruption of parasite transmission through a little-documented vector control campaign in 1995. Despite the efficacy of the 1995 control campaign, T. cruzi was rapidly reemerging in vector populations in La Joya, emphasizing the need for continuing surveillance and control at the rural-urban interface.

Original languageEnglish (US)
Title of host publicationPLoS Neglected Tropical Diseases
Volume5
Edition2
DOIs
StatePublished - Feb 2011

Fingerprint

Peru
Chagas Disease
Trypanosoma cruzi
Human Migration
History
Insect Vectors
Parasitic Diseases
Newspapers
Bayes Theorem
Incidence
Infection
Documentation
Cluster Analysis
Parasites
Population

ASJC Scopus subject areas

  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Delgado, S., Neyra, R. C., Machaca, V. R. Q., Juárez, J. A., Chu, L. C., Verastegui, M. R., ... Levy, M. Z. (2011). A history of Chagas disease transmission, control, and re-emergence in peri-rural La Joya, Peru. In PLoS Neglected Tropical Diseases (2 ed., Vol. 5). [e970] https://doi.org/10.1371/journal.pntd.0000970

A history of Chagas disease transmission, control, and re-emergence in peri-rural La Joya, Peru. / Delgado, Stephen; Neyra, Ricardo Castillo; Machaca, Víctor R Quispe; Juárez, Jenny Ancca; Chu, Lily Chou; Verastegui, Manuela Renee; Apaza, Giovanna M Moscoso; Bocángel, César D.; Tustin, Aaron W.; Sterling, Charles R; Comrie, Andrew; Náquira, César; del Carpio, Juan G Cornejo; Gilman, Robert H.; Bern, Caryn; Levy, Michael Z.

PLoS Neglected Tropical Diseases. Vol. 5 2. ed. 2011. e970.

Research output: Chapter in Book/Report/Conference proceedingChapter

Delgado, S, Neyra, RC, Machaca, VRQ, Juárez, JA, Chu, LC, Verastegui, MR, Apaza, GMM, Bocángel, CD, Tustin, AW, Sterling, CR, Comrie, A, Náquira, C, del Carpio, JGC, Gilman, RH, Bern, C & Levy, MZ 2011, A history of Chagas disease transmission, control, and re-emergence in peri-rural La Joya, Peru. in PLoS Neglected Tropical Diseases. 2 edn, vol. 5, e970. https://doi.org/10.1371/journal.pntd.0000970
Delgado S, Neyra RC, Machaca VRQ, Juárez JA, Chu LC, Verastegui MR et al. A history of Chagas disease transmission, control, and re-emergence in peri-rural La Joya, Peru. In PLoS Neglected Tropical Diseases. 2 ed. Vol. 5. 2011. e970 https://doi.org/10.1371/journal.pntd.0000970
Delgado, Stephen ; Neyra, Ricardo Castillo ; Machaca, Víctor R Quispe ; Juárez, Jenny Ancca ; Chu, Lily Chou ; Verastegui, Manuela Renee ; Apaza, Giovanna M Moscoso ; Bocángel, César D. ; Tustin, Aaron W. ; Sterling, Charles R ; Comrie, Andrew ; Náquira, César ; del Carpio, Juan G Cornejo ; Gilman, Robert H. ; Bern, Caryn ; Levy, Michael Z. / A history of Chagas disease transmission, control, and re-emergence in peri-rural La Joya, Peru. PLoS Neglected Tropical Diseases. Vol. 5 2. ed. 2011.
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