A light-fluence-independent method for the quantitative analysis of dynamic contrast-enhanced multispectral optoacoustic tomography (DCE MSOT)

Clinton W. Hupple, Stefan Morscher, Neal C. Burton, Mark D. Pagel, Lacey R. McNally, Julio Cárdenas-Rodríguez

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

MultiSpectral Optoacoustic Tomography (MSOT) is an emerging imaging technology that allows for data acquisition at high spatial and temporal resolution. These imaging characteristics are advantageous for Dynamic Contrast Enhanced (DCE) imaging that can assess the combination of vascular flow and permeability. However, the quantitative analysis of DCE MSOT data has not been possible due to complications caused by wavelength-dependent light attenuation and variability in light fluence at different anatomical locations. In this work we present a new method for the quantitative analysis of DCE MSOT data that is not biased by light fluence. We have named this method the two-compartment linear standard model (2C-LSM) for DCE MSOT.

Original languageEnglish (US)
Pages (from-to)54-64
Number of pages11
JournalPhotoacoustics
Volume10
DOIs
StatePublished - Jun 2018

Keywords

  • Dynamic contrast enhanced imaging
  • Linear models
  • Multispectral optoacoustic tomography
  • Permeability
  • Pharmacokinetics models

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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