A linear structural equation model for covert verb generation based on independent component analysis of fMRI data from children and adolescents

Prasanna Karunanayaka, Vincent J. Schmithorst, Jennifer Vannest, Jerzy P. Szaflarski, Elena M Plante, Scott K. Holland

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Human language is a complex and protean cognitive ability. Young children, following well defined developmental patterns learn language rapidly and effortlessly producing full sentences by the age of 3 years. However, the language circuitry continues to undergo significant neuroplastic changes extending well into teenage years. Evidence suggests that the developing brain adheres to two rudimentary principles of functional organization: functional integration and functional specialization. At a neurobiological level, this distinction can be identified with progressive specialization or focalization reflecting consolidation and synaptic reinforcement of a network (Lenneberg, 1967; Muller et al., 1998; Berl et al., 2006). In this paper, we used group independent component analysis and linear structural equation modeling (McIntosh and Gonzalez-Lima, 1994; Karunanayaka et al., 2007) to tease out the developmental trajectories of the language circuitry based on fMRI data from 336 children ages 5-18 years performing a blocked, covert verb generation task. The results are analyzed and presented in the framework of theoretical models for neurocognitive brain development. This study highlights the advantages of combining both modular and connectionist approaches to cognitive functions; from a methodological perspective, it demonstrates the feasibility of combining data-driven and hypothesis driven techniques to investigate the developmental shifts in the semantic network.

Original languageEnglish (US)
Article number29
JournalFrontiers in Systems Neuroscience
Issue numberJUNE 2011
DOIs
StatePublished - Jun 1 2011

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Structural Models
Language
Magnetic Resonance Imaging
Aptitude
Brain
Semantics
Cognition
Theoretical Models

Keywords

  • Brain development
  • Child
  • fMRI
  • Functional neuroimaging
  • Language
  • Pediatric

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Developmental Neuroscience

Cite this

A linear structural equation model for covert verb generation based on independent component analysis of fMRI data from children and adolescents. / Karunanayaka, Prasanna; Schmithorst, Vincent J.; Vannest, Jennifer; Szaflarski, Jerzy P.; Plante, Elena M; Holland, Scott K.

In: Frontiers in Systems Neuroscience, No. JUNE 2011, 29, 01.06.2011.

Research output: Contribution to journalArticle

Karunanayaka, Prasanna ; Schmithorst, Vincent J. ; Vannest, Jennifer ; Szaflarski, Jerzy P. ; Plante, Elena M ; Holland, Scott K. / A linear structural equation model for covert verb generation based on independent component analysis of fMRI data from children and adolescents. In: Frontiers in Systems Neuroscience. 2011 ; No. JUNE 2011.
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