A meta-analysis of MSI frequency and race in colorectal cancer

Hassan Ashktorab, Sadhna Ahuja, Lakshmi Kannan, Xavier Llor, Nathan Ellis, Rosa M. Xicola, Adeyinka O. Laiyemo, John M. Carethers, Hassan Brim, Mehdi Nouraie

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

PURPOSE: African Americans (AA) are at a higher risk of colorectal cancer (CRC) and some studies report a higher frequency of microsatellite instability (MSI) in this population while others report lower frequency compared to Caucasians. AIM: To determine and evaluate the association of race and clinical factors with MSI frequency through meta- analysis. METHODS: Twenty-two studies out of 15,105 (1997-2015) were evaluated after a search in different literature databases, using keywords "colorectal cancer, microsatellite instability, African Americans, Caucasians and Hispanics". We used random effect meta-analysis to calculate the MSI frequency in all studies as well as in African American and Caucasian samples. Meta-regression analysis was used to assess the univariate effect of race, gender, age, tumor location and stage on MSI frequency. RESULTS: The overall MSI frequency among CRCs was 17% (95%CI: 15%-19%, I2=91%). In studies with available race data, The MSI rate among AAs, Hispanics and Caucasians were 12%, 12% and 14% respectively and was not significantly different. Sub-group analysis of studies with racial information indicates MSI OR of 0.78 for AAs compared to Caucasians. CONCLUSION: CRCs demonstrate an overall MSI frequency of 17%. MSI frequency differences between AAs and Caucasians were not pronounced, suggesting that other factors contribute to the racial disparity. The methodological approaches and biological sources of the variation seen in MSI frequency between different studies need to be further investigated.

Original languageEnglish (US)
Pages (from-to)34546-34557
Number of pages12
JournalOncotarget
Volume7
Issue number23
DOIs
StatePublished - Jun 7 2016

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Microsatellite Instability
Meta-Analysis
Colorectal Neoplasms
African Americans
Hispanic Americans
Regression Analysis
Databases

Keywords

  • African americans
  • Caucasians
  • Colorectal cancer
  • Hispanics
  • MSI

ASJC Scopus subject areas

  • Oncology

Cite this

Ashktorab, H., Ahuja, S., Kannan, L., Llor, X., Ellis, N., Xicola, R. M., ... Nouraie, M. (2016). A meta-analysis of MSI frequency and race in colorectal cancer. Oncotarget, 7(23), 34546-34557. https://doi.org/10.18632/oncotarget.8945

A meta-analysis of MSI frequency and race in colorectal cancer. / Ashktorab, Hassan; Ahuja, Sadhna; Kannan, Lakshmi; Llor, Xavier; Ellis, Nathan; Xicola, Rosa M.; Laiyemo, Adeyinka O.; Carethers, John M.; Brim, Hassan; Nouraie, Mehdi.

In: Oncotarget, Vol. 7, No. 23, 07.06.2016, p. 34546-34557.

Research output: Contribution to journalArticle

Ashktorab, H, Ahuja, S, Kannan, L, Llor, X, Ellis, N, Xicola, RM, Laiyemo, AO, Carethers, JM, Brim, H & Nouraie, M 2016, 'A meta-analysis of MSI frequency and race in colorectal cancer', Oncotarget, vol. 7, no. 23, pp. 34546-34557. https://doi.org/10.18632/oncotarget.8945
Ashktorab H, Ahuja S, Kannan L, Llor X, Ellis N, Xicola RM et al. A meta-analysis of MSI frequency and race in colorectal cancer. Oncotarget. 2016 Jun 7;7(23):34546-34557. https://doi.org/10.18632/oncotarget.8945
Ashktorab, Hassan ; Ahuja, Sadhna ; Kannan, Lakshmi ; Llor, Xavier ; Ellis, Nathan ; Xicola, Rosa M. ; Laiyemo, Adeyinka O. ; Carethers, John M. ; Brim, Hassan ; Nouraie, Mehdi. / A meta-analysis of MSI frequency and race in colorectal cancer. In: Oncotarget. 2016 ; Vol. 7, No. 23. pp. 34546-34557.
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