A meta-analysis of risk estimates for prostate cancer related to tire and rubber manufacturing operations

Ronald E. Stewart, Leslie K. Dennis, Deborah V. Dawson, Martin I. Resnick

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Studies investigating the association between prostate cancer and exposure to the tire and rubber manufacturing environment have reported weak and inconsistent results. A meta-analysis of nine cohort studies that used standard mortality ratios and three case-control studies that used odds ratios was conducted. The pooled results from the nine cohort studies showed a standard mortality ratio of 101 (95% confidence interval [CI] = 93, 110), whereas the pooled results from the three case-control studies showed an odds ratio of 1.10 (95% CI = O. 94, 1.29). The standard mortality ratios were converted to odds ratios by dividing by 100. The overall pooled risk estimate from all 12 studies was 1.03 (95 % CI = 0. 96, 1.11). The conclusion of this meta-analysis is that work exposure in a rubber and tire manufacturing environment does not result in an increased risk of prostate cancer.

Original languageEnglish (US)
Pages (from-to)1079-1084
Number of pages6
JournalJournal of occupational and environmental medicine
Volume41
Issue number12
DOIs
StatePublished - Dec 1999
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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