A method for the rapid estimation of sublimation rates of organic compounds at standard temperature and pressure

Marc Tesconi, Michael J. Pikal, Samuel H Yalkowsky

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A method for the rapid estimation of the sublimation rates of organic compounds at standard temperature and pressure (STP; 298 K and 101.3 kPa, respectively) is presented. Thermogravimetric analysis was used to obtain accelerated sublimation rates for anthracene at a series of elevated temperatures and reduced pressures. An empirical equation relating these parameters was used to extrapolate to the STP sublimation rate. This value is in good agreement with the measured value.

Original languageEnglish (US)
Pages (from-to)1299-1302
Number of pages4
JournalJournal of Pharmaceutical Sciences
Volume86
Issue number11
DOIs
StatePublished - Nov 1997

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Sublimation
Organic compounds
Pressure
Temperature
Thermogravimetric analysis

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science

Cite this

A method for the rapid estimation of sublimation rates of organic compounds at standard temperature and pressure. / Tesconi, Marc; Pikal, Michael J.; Yalkowsky, Samuel H.

In: Journal of Pharmaceutical Sciences, Vol. 86, No. 11, 11.1997, p. 1299-1302.

Research output: Contribution to journalArticle

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