A microfluidic-based platform for in vitro studies of cell signaling in blood vessels

R. Riahi, Y. Yang, H. Kim, L. Jiang, Pak Kin Wong, Yitshak Zohar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A microfluidic-based platform is developed for in vitro investigation of signaling within the blood-stream leading to preferential homing of specific cells such as white blood cells (WBCs) selectively to injured host organs. A microchannel has been coated with a monolayer of endothelial cells to mimic the microenvironment in blood vessels, while stable chemokine gradients have been generated locally at selected locations along the microchannel sidewalls. We demonstrate that both the chemokine gradients and the endothelial cells are simultaneously maintained during steady flow of cells as in the blood stream.

Original languageEnglish (US)
Title of host publication2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013
Pages293-296
Number of pages4
DOIs
StatePublished - 2013
Event2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013 - Barcelona, Spain
Duration: Jun 16 2013Jun 20 2013

Other

Other2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013
CountrySpain
CityBarcelona
Period6/16/136/20/13

Fingerprint

Cell signaling
Blood vessels
Microfluidics
Blood
Endothelial cells
Microchannels
Steady flow
Monolayers
Cells

Keywords

  • cell signaling
  • chemokine gradients
  • endothelial cells
  • Microfluidic system

ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering

Cite this

Riahi, R., Yang, Y., Kim, H., Jiang, L., Wong, P. K., & Zohar, Y. (2013). A microfluidic-based platform for in vitro studies of cell signaling in blood vessels. In 2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013 (pp. 293-296). [6626760] https://doi.org/10.1109/Transducers.2013.6626760

A microfluidic-based platform for in vitro studies of cell signaling in blood vessels. / Riahi, R.; Yang, Y.; Kim, H.; Jiang, L.; Wong, Pak Kin; Zohar, Yitshak.

2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013. 2013. p. 293-296 6626760.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Riahi, R, Yang, Y, Kim, H, Jiang, L, Wong, PK & Zohar, Y 2013, A microfluidic-based platform for in vitro studies of cell signaling in blood vessels. in 2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013., 6626760, pp. 293-296, 2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013, Barcelona, Spain, 6/16/13. https://doi.org/10.1109/Transducers.2013.6626760
Riahi R, Yang Y, Kim H, Jiang L, Wong PK, Zohar Y. A microfluidic-based platform for in vitro studies of cell signaling in blood vessels. In 2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013. 2013. p. 293-296. 6626760 https://doi.org/10.1109/Transducers.2013.6626760
Riahi, R. ; Yang, Y. ; Kim, H. ; Jiang, L. ; Wong, Pak Kin ; Zohar, Yitshak. / A microfluidic-based platform for in vitro studies of cell signaling in blood vessels. 2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013. 2013. pp. 293-296
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