A multidisciplinary approach to the diagnosis of cutaneous t-cell lymphomas

Claire M. Payne, Thomas M. Grogan, Catherine M. Spier, Charles G. Bjore, Lynne C. Richter, Douglas W. Cromey, Catherine S. Rangel

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The cutaneous T-cell lymphomas (CTCLs) comprise a spectrum of non-Hodgkin lymphomas with a predilection for the skin. This heterogeneous group of CTCLs include the prototypic CTCL mycosis fun-goides (MF) and the recently described Ki-1 + lymphomas. MF is notoriously difficult to diagnose in its early stages. The histologic appearance of early MF is indistinguishable from that of chronic dermatitis. The limitations of light microscopy in the diagnosis of the CTCLs have led to the development of other diagnostic laboratory techniques. The best approach to the diagnosis of the CTCLs is a multi-disciplinary one and should include ultrastructural morphometry, immunophenotyping, immunogeno-typing, and histologic evaluation whenever possible. It is the purpose of this overview to point out the strengths and weaknesses of each of these techniques and, together with clinical input, to provide a comprehensive and rational approach to patient care.

Original languageEnglish (US)
Pages (from-to)99-125
Number of pages27
JournalUltrastructural Pathology
Volume16
Issue number1-2
DOIs
StatePublished - Jan 1 1992

Keywords

  • Cutaneous
  • Immunophenotyping
  • Lymphoma
  • Morphometry
  • Ultrastructure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology

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  • Cite this

    Payne, C. M., Grogan, T. M., Spier, C. M., Bjore, C. G., Richter, L. C., Cromey, D. W., & Rangel, C. S. (1992). A multidisciplinary approach to the diagnosis of cutaneous t-cell lymphomas. Ultrastructural Pathology, 16(1-2), 99-125. https://doi.org/10.3109/01913129209074555