A multifaceted prospective memory intervention to improve medication adherence: Design of a randomized control trial

Kathleen C. Insel, Gilles O. Einstein, Daniel G. Morrow, Joseph T. Hepworth

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Adherence to prescribed antihypertensive agents is critical because control of elevated blood pressure is the single most important way to prevent stroke and other end organ damage. Unfortunately, nonadherence remains a significant problem. Previous interventions designed to improve adherence have demonstrated only small benefits of strategies that target single facets such as understanding medication directions. The intervention described here is informed by prospective memory theory and performance of older adults in laboratory-based paradigms and uses a comprehensive, multifaceted approach to improve adherence. It incorporates multiple strategies designed to support key components of prospective remembering involved in taking medication. The intervention is delivered by nurses in the home with an education control group for comparison. Differences between groups in overall adherence following the intervention and 6. months later will be tested. Systolic and diastolic blood pressure levels also will be examined between groups and as they relate to adherence. Intra-individual regression is planned to examine change in adherence over time and its predictors. Finally, we will examine the association between executive function/working memory and adherence, predicting that adherence will be related to executive/working memory in the control group but not in the intervention group.

Original languageEnglish (US)
Pages (from-to)45-52
Number of pages8
JournalContemporary Clinical Trials
Volume34
Issue number1
DOIs
StatePublished - Jan 1 2013

Keywords

  • Cognition
  • Hypertension
  • Intervention
  • Medication adherence
  • Prospective memory
  • Self-management

ASJC Scopus subject areas

  • Pharmacology (medical)

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