A multiscale biomechanical model of platelets: Correlating with in-vitro results

Peng Zhang, Li Zhang, Marvin J. Slepian, Yuefan Deng, Danny Bluestein

Research output: Research - peer-reviewArticle

  • 1 Citations

Abstract

Using dissipative particle dynamics (DPD) combined with coarse grained molecular dynamics (CGMD) approaches, we developed a multiscale deformable platelet model to accurately describe the molecular-scale intra-platelet constituents and biomechanical properties of platelets in blood flow. Our model includes the platelet bilayer membrane, cytoplasm and an elaborate elastic cytoskeleton. Correlating numerical simulations with published in-vitro experiments, we validated the biorheology of the cytoplasm, the elastic response of membrane to external stresses, and the stiffness of the cytoskeleton actin filaments, resulting in an accurate representation of the molecular-level biomechanical microstructures of platelets. This enabled us to study the mechanotransduction process of the hemodynamic stresses acting onto the platelet membrane and transmitted to these intracellular constituents. The platelets constituents continuously deform in response to the flow induced stresses. To the best of our knowledge, this is the first molecular-scale platelet model that can be used to accurately predict platelets activation mechanism leading to thrombus formation in prosthetic cardiovascular devices and in vascular disease processes. This model can be further employed to study the effects of novel therapeutic approaches of modulating platelet properties to enhance their shear resistance via mechanotransduction pathways.

LanguageEnglish (US)
Pages26-33
Number of pages8
JournalJournal of Biomechanics
Volume50
DOIs
StatePublished - Jan 4 2017

Fingerprint

Blood Platelets
In Vitro Techniques
Platelets
Membranes
Cytoskeleton
Cytoplasm
Platelet Activation
Therapeutic Uses
Molecular Dynamics Simulation
Actin Cytoskeleton
Vascular Diseases
Thrombosis
Hemodynamics
Equipment and Supplies
Prosthetics
Molecular dynamics
Blood
Chemical activation
Stiffness
Microstructure

Keywords

  • Biomechanical
  • Mechanotransduction
  • Multiscale modeling
  • Platelets
  • Thrombosis

ASJC Scopus subject areas

  • Biophysics
  • Orthopedics and Sports Medicine
  • Biomedical Engineering
  • Rehabilitation

Cite this

A multiscale biomechanical model of platelets : Correlating with in-vitro results. / Zhang, Peng; Zhang, Li; Slepian, Marvin J.; Deng, Yuefan; Bluestein, Danny.

In: Journal of Biomechanics, Vol. 50, 04.01.2017, p. 26-33.

Research output: Research - peer-reviewArticle

Zhang, Peng ; Zhang, Li ; Slepian, Marvin J. ; Deng, Yuefan ; Bluestein, Danny. / A multiscale biomechanical model of platelets : Correlating with in-vitro results. In: Journal of Biomechanics. 2017 ; Vol. 50. pp. 26-33
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