A new case of γ-heavy chain disease. Clinical and immunochemical studies

F. Cozzolino, Donata Vercelli, E. Castigli, A. Becucci, R. Di Guglielmo

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The detection of a γ-heavy chain disease protein in the serum and urine of a patient with a history of Hodgkin's disease in complete remission is reported. The protein has been characterized as a γ1 dimer, MW 66000, beginning at Asp 221 residue in the hinge region. No cliical or laboratory findings of malignancy have been observed in the patient since the abnormal protein was detected. The pathogenesis of this association, unreported to date, is discussed on the basis of previously administered high-dose anti-neoplastic treatments and of immunological impairment.

Original languageEnglish (US)
Pages (from-to)145-150
Number of pages6
JournalScandinavian Journal of Haematology
Volume28
Issue number2
StatePublished - 1982
Externally publishedYes

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Heavy Chain Disease
Hodgkin Disease
Blood Proteins
Proteins
Urine
Neoplasms
Clinical Studies
Therapeutics

ASJC Scopus subject areas

  • Hematology

Cite this

Cozzolino, F., Vercelli, D., Castigli, E., Becucci, A., & Di Guglielmo, R. (1982). A new case of γ-heavy chain disease. Clinical and immunochemical studies. Scandinavian Journal of Haematology, 28(2), 145-150.

A new case of γ-heavy chain disease. Clinical and immunochemical studies. / Cozzolino, F.; Vercelli, Donata; Castigli, E.; Becucci, A.; Di Guglielmo, R.

In: Scandinavian Journal of Haematology, Vol. 28, No. 2, 1982, p. 145-150.

Research output: Contribution to journalArticle

Cozzolino, F, Vercelli, D, Castigli, E, Becucci, A & Di Guglielmo, R 1982, 'A new case of γ-heavy chain disease. Clinical and immunochemical studies', Scandinavian Journal of Haematology, vol. 28, no. 2, pp. 145-150.
Cozzolino, F. ; Vercelli, Donata ; Castigli, E. ; Becucci, A. ; Di Guglielmo, R. / A new case of γ-heavy chain disease. Clinical and immunochemical studies. In: Scandinavian Journal of Haematology. 1982 ; Vol. 28, No. 2. pp. 145-150.
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