A new machine for automated solid phase peptide synthesis

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Abstract

A versatile, fail-safe, and simple machine for automated solid phase peptide synthesis was designed and constructed. A dual programming scheme was used. The variable operations such as kind and quantity of solvent or reagent, reaction or wash times, and other variables, are controlled by a Drum Programmer. The repetitive operations needed to get the solvent or reagent into and out of the reaction vessel are controlled by a Card Programmer. A number of failsafe devices were built into the machine to shut it off if electrical or mechanical failures occur. The operation is also monitored with a strip chart recorder which gives a permanent record of a synthesis. The machine can be operated in both automatic and manual modes.

Original languageEnglish (US)
Pages (from-to)343-350
Number of pages8
JournalAnalytical Chemistry
Volume44
Issue number2
Publication statusPublished - 1972

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ASJC Scopus subject areas

  • Analytical Chemistry

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