A new nonionic macrocyclic gadolinium(III) chelate as a potential magnetic-resonance-imaging contrast agent

Michiko B. Inoue, Paul Oram, Motomichi Inoue, Quintus Fernando, Andrew L. Alexander, Evan C. Unger

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A new GdIII complex of a 17-membered macrocycle with three pendant carboxymethyl groups has been synthesized; the ligand has been obtained in a single step from diethylenetriaminepentaacetic dianhydride (pentetic dianhydride) and 1,4-butanediamine (putrescine). An X-ray crystal analysis has shown that the complex is a nonionic metal chelate with a coordinated water molecule. The near-zero electrical conductivity, 1 Ω-1 cm2 mol-1, of a 1 mM solution indicated that the metal chelate is essentially undissociated. The NMR T1 relaxivity is 2.5 s-1 mM-1 at a resonance field of 64 MHz, and 3.4 s-1 mM-1 at 250 MHz. This new GdIII complex is a potentially important magnetic resonance imaging contrast agent.

Original languageEnglish (US)
Pages (from-to)429-432
Number of pages4
JournalMagnetic Resonance Imaging
Volume12
Issue number3
DOIs
StatePublished - 1994

Keywords

  • MRI contrast agent
  • Nonionic gadolinium chelate

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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