A New Parenteral Emulsion for the Administration of Taxol

B. D. Tarr, T. G. Sambandan, S. H. Yalkowsky

Research output: Contribution to journalArticlepeer-review

120 Scopus citations

Abstract

Taxol (NSC-125973) is a poorly soluble plant product that exhibits excellent antimitotic properties. This study involves the development of a new formulation for taxol. The stability of taxol in a 50% triacetin emulsion as well as possible methods of intravenous administration of this dosage form was examined. A stable emulsion was found at taxol concentrations of 10 and 15 mg/ml of emulsion. The 50% triacetin emulsion showed an intravenous LD50 of 1.2 ml/kg in Swiss-Webster mice. The 10 mg/ml taxol formulation was demonstrated to be stable upon addition to 5% dextrose iv fluids provided that small packing systems were used. The taxol–triacetin emulsion can also be intravenously injected at various rates, and it may prove to be a useful formulation for taxol.

Original languageEnglish (US)
Pages (from-to)162-165
Number of pages4
JournalPharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists
Volume4
Issue number2
DOIs
StatePublished - Apr 1987

Keywords

  • formulation
  • taxol
  • toxicity of triacetin
  • water-soluble emulsion

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)

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