A new parenteral vehicle was developed for three poorly water soluble anti-cancer drugs using pluronic L64. A ternary cosolvent system containing pluronic L64 (60%), ethanol (30%), and polysorbate 80 (10%) was formulated. All three drugs tested were stable in this vehicle. Methods of administration usually involve a simple dilution of one part formulation with 2 parts water. The water-diluted formulation of the three drugs studies is physically stable for three days prior to crystallization.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of Parenteral Science and Technology|
|State||Published - Jan 1 1987|
ASJC Scopus subject areas
- Pharmaceutical Science