A new parenteral vehicle for the adminstration of some poorly water soluble anti-cancer drugs

B. D. Tarr, S. H. Yalkowsky

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

A new parenteral vehicle was developed for three poorly water soluble anti-cancer drugs using pluronic L64. A ternary cosolvent system containing pluronic L64 (60%), ethanol (30%), and polysorbate 80 (10%) was formulated. All three drugs tested were stable in this vehicle. Methods of administration usually involve a simple dilution of one part formulation with 2 parts water. The water-diluted formulation of the three drugs studies is physically stable for three days prior to crystallization.

Original languageEnglish (US)
Pages (from-to)31-33
Number of pages3
JournalJournal of Parenteral Science and Technology
Volume41
Issue number1
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Pharmaceutical Science

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