A new role for PGRP-S (Tag7) in immune defense

Lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1

E. A. Dukhanina, T. I. Lukyanova, E. A. Romanova, Vincent Guerriero, N. V. Gnuchev, G. P. Georgiev, D. V. Yashin, L. P. Sashchenko

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

PGRP-S (Tag7) is an innate immunity protein involved in the antimicrobial defense systems, both in insects and in mammals. We have previously shown that Tag7 specifically interacts with several proteins, including Hsp70 and the calcium binding protein S100A4 (Mts1), providing a number of novel cellular functions. Here we show that Tag7–Mts1 complex causes chemotactic migration of lymphocytes, with NK cells being a preferred target. Cells of either innate immunity (neutrophils and monocytes) or acquired immunity (CD4+ and CD8+ lymphocytes) can produce this complex, which confirms the close connection between components of the 2 branches of immune response.

Original languageEnglish (US)
Pages (from-to)3635-3643
Number of pages9
JournalCell Cycle
Volume14
Issue number22
DOIs
StatePublished - 2015

Fingerprint

Chemotactic Factors
Innate Immunity
Lymphocytes
Calcium-Binding Proteins
Adaptive Immunity
Natural Killer Cells
Insects
Monocytes
Mammals
Proteins
Neutrophils

Keywords

  • Chemotaxis
  • Human lymphocytes
  • Mts1
  • NK cells
  • Tag7
  • Tag7-Mts1 complex

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Cite this

Dukhanina, E. A., Lukyanova, T. I., Romanova, E. A., Guerriero, V., Gnuchev, N. V., Georgiev, G. P., ... Sashchenko, L. P. (2015). A new role for PGRP-S (Tag7) in immune defense: Lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1. Cell Cycle, 14(22), 3635-3643. https://doi.org/10.1080/15384101.2015.1104440

A new role for PGRP-S (Tag7) in immune defense : Lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1. / Dukhanina, E. A.; Lukyanova, T. I.; Romanova, E. A.; Guerriero, Vincent; Gnuchev, N. V.; Georgiev, G. P.; Yashin, D. V.; Sashchenko, L. P.

In: Cell Cycle, Vol. 14, No. 22, 2015, p. 3635-3643.

Research output: Contribution to journalArticle

Dukhanina, EA, Lukyanova, TI, Romanova, EA, Guerriero, V, Gnuchev, NV, Georgiev, GP, Yashin, DV & Sashchenko, LP 2015, 'A new role for PGRP-S (Tag7) in immune defense: Lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1', Cell Cycle, vol. 14, no. 22, pp. 3635-3643. https://doi.org/10.1080/15384101.2015.1104440
Dukhanina, E. A. ; Lukyanova, T. I. ; Romanova, E. A. ; Guerriero, Vincent ; Gnuchev, N. V. ; Georgiev, G. P. ; Yashin, D. V. ; Sashchenko, L. P. / A new role for PGRP-S (Tag7) in immune defense : Lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1. In: Cell Cycle. 2015 ; Vol. 14, No. 22. pp. 3635-3643.
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