A new strategy for the synthesis of four individual isomers of β-methylphenylalanine

F. D. Lung, G. Li, B. S. Lou, Victor J Hruby

Research output: Contribution to journalArticle

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Abstract

The application of an allylic strain effect in boron enolates and asymmetric Michael-like addition/electrophilic bromination reactions is reported for the asymmetric synthesis of the individual isomers of unusual constrained amino acids. For β-substituted α-amino acids, all of the final optically pure products were identical to authentic samples, which provided further and unequivocal evidence to confirm the assignments of stereochemical control of the new methods in this report.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalSynthetic Communications
Volume25
Issue number1
StatePublished - 1995

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Isomers
Amino Acids
Boron

ASJC Scopus subject areas

  • Organic Chemistry

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A new strategy for the synthesis of four individual isomers of β-methylphenylalanine. / Lung, F. D.; Li, G.; Lou, B. S.; Hruby, Victor J.

In: Synthetic Communications, Vol. 25, No. 1, 1995, p. 57-61.

Research output: Contribution to journalArticle

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