A New Synthesis of 2-Substituted 6-endo-(Methylthio)bicyclo[2.2.1]heptanes. Synthesis and Crystal and Molecular Structure of a Conformationally Restricted Methionine Analogue

Richard S. Glass, Mahmood Sabahi, Waheguru P. Singh

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A new and advantageous synthesis of 2-endo-substituted-6-endo-(methylthio)bicyclo [2.2.1]heptanes, especially suitable for the preparation of such compounds with 2-endo-hydroxy and amino substituents, is presented. Also reported is the synthesis of the conformationally restricted methionine analogue (±)-2-endo-amino-6-endo-(methylthio)bicyclo[2.2.1]heptane-2-exo-carboxylic acid and its crystal and molecular structure determined by X-ray crystallographic techniques.

Original languageEnglish (US)
Pages (from-to)2683-2688
Number of pages6
JournalJournal of Organic Chemistry
Issue number9
StatePublished - Apr 1 1992


ASJC Scopus subject areas

  • Organic Chemistry

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