A new total body potassium method to estimate total body skeletal muscle mass in children

ZiMian Wang, Stanley Heshka, Angelo Pietrobelli, Zhao Chen, Analiza M. Silva, Luis B. Sardinha, Jack Wang, Dympna Gallager, Steven B. Heymsfield

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A whole body skeletal muscle [(SM); kg] mass estimation model, based on total body potassium [(TBK); mmol] measured by whole body 40K counting (WBC) was developed (SM = 0.0082 ·TBK) and validated in adults in a previous study. It is unknown whether the adult TBK SM prediction model is applicable for pediatric use. The aim of this study was to derive and validate a pediatric TBK SM prediction equation. SM measured by MRI was used as the criterion and TBK was measured by WBC. The protocol was completed in 116 healthy children, 66 males and 50 females, 11.7 ± 3.5 y (mean ± SD, range = 5-17 y). A strong linear correlation was observed between TBK and SM (r = 0.984; P < 0.001). The SM:TBK ratio was 0.0071 ± 0.0008 kg/mmol in the children studied, much lower than the corresponding value of 0.0082 kg/mmol in adults. An empirical SM prediction equation was developed using TBK alone: SM = 0.0085·TBK - 2.83, r2 = 0.97, SEE = 1.39 kg. Bland-Altman analysis did not disclose a significant bias in the prediction of SM. When biological factors entered along with TBK in the general linear model, another prediction equation was developed: SM = 5.52 + 0.001·TBK (mmol)+ 0.081·weight (kg) - 0.049·height (cm) + 0.00004·TBK · height + race (-0.60 for Caucasian, 0.49 for African-American, and 0 for Hispanic). Because the adult TBK SM prediction model is not applicable for pediatric use, this study provides new empirical TBK SM prediction equations that should prove useful for studies on nutrition, growth, and development in children.

Original languageEnglish (US)
Pages (from-to)1988-1991
Number of pages4
JournalJournal of Nutrition
Volume137
Issue number8
StatePublished - Aug 2007

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skeletal muscle
Potassium
Skeletal Muscle
potassium
prediction
methodology
Whole-Body Counting
Pediatrics
child nutrition
Biological Factors
African Americans
Growth and Development
Hispanic Americans
Linear Models
growth and development
linear models

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Wang, Z., Heshka, S., Pietrobelli, A., Chen, Z., Silva, A. M., Sardinha, L. B., ... Heymsfield, S. B. (2007). A new total body potassium method to estimate total body skeletal muscle mass in children. Journal of Nutrition, 137(8), 1988-1991.

A new total body potassium method to estimate total body skeletal muscle mass in children. / Wang, ZiMian; Heshka, Stanley; Pietrobelli, Angelo; Chen, Zhao; Silva, Analiza M.; Sardinha, Luis B.; Wang, Jack; Gallager, Dympna; Heymsfield, Steven B.

In: Journal of Nutrition, Vol. 137, No. 8, 08.2007, p. 1988-1991.

Research output: Contribution to journalArticle

Wang, Z, Heshka, S, Pietrobelli, A, Chen, Z, Silva, AM, Sardinha, LB, Wang, J, Gallager, D & Heymsfield, SB 2007, 'A new total body potassium method to estimate total body skeletal muscle mass in children', Journal of Nutrition, vol. 137, no. 8, pp. 1988-1991.
Wang Z, Heshka S, Pietrobelli A, Chen Z, Silva AM, Sardinha LB et al. A new total body potassium method to estimate total body skeletal muscle mass in children. Journal of Nutrition. 2007 Aug;137(8):1988-1991.
Wang, ZiMian ; Heshka, Stanley ; Pietrobelli, Angelo ; Chen, Zhao ; Silva, Analiza M. ; Sardinha, Luis B. ; Wang, Jack ; Gallager, Dympna ; Heymsfield, Steven B. / A new total body potassium method to estimate total body skeletal muscle mass in children. In: Journal of Nutrition. 2007 ; Vol. 137, No. 8. pp. 1988-1991.
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