A novel comprehensive wave-form MS data processing method

Shuo Chen, Ming Li, Don Hong, David D Billheimer, Huiming Li, Baogang J. Xu, Yu Shyr

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Motivation: Mass spectrometry (MS) can generate high-throughput protein profiles for biomedical research to discover biologically related protein patterns-biomarkers. The noisy functional MS data collected by current technologies, however, require consistent, sensitive and robust data-processing techniques for successful biomedical application. Therefore, it is important to detect features precisely for each spectrum, quantify them well and assign a unique label to features from the same protein-peptide across spectra. Results: In this article, we propose a new comprehensive MS data preprocessing package, Wave-spec, which includes several novel algorithms. It can overcome several conventional difficulties. Wave-spec can be applied to multiple types of MS data generated with different MS technologies. Results from this new package were evaluated and compared to several existing approaches based on a MALDI-TOF MS dataset.

Original languageEnglish (US)
Pages (from-to)808-814
Number of pages7
JournalBioinformatics
Volume25
Issue number6
DOIs
StatePublished - Mar 2009
Externally publishedYes

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Data Processing Methods
Mass Spectrometry
Waveform
Mass spectrometry
Proteins
Protein
Technology
Data Preprocessing
Biomedical Applications
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Biomarkers
Peptides
High Throughput
Assign
Biomedical Research
Labels
Quantify
Throughput

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Computational Theory and Mathematics
  • Computer Science Applications
  • Computational Mathematics
  • Statistics and Probability

Cite this

A novel comprehensive wave-form MS data processing method. / Chen, Shuo; Li, Ming; Hong, Don; Billheimer, David D; Li, Huiming; Xu, Baogang J.; Shyr, Yu.

In: Bioinformatics, Vol. 25, No. 6, 03.2009, p. 808-814.

Research output: Contribution to journalArticle

Chen, S, Li, M, Hong, D, Billheimer, DD, Li, H, Xu, BJ & Shyr, Y 2009, 'A novel comprehensive wave-form MS data processing method', Bioinformatics, vol. 25, no. 6, pp. 808-814. https://doi.org/10.1093/bioinformatics/btp060
Chen, Shuo ; Li, Ming ; Hong, Don ; Billheimer, David D ; Li, Huiming ; Xu, Baogang J. ; Shyr, Yu. / A novel comprehensive wave-form MS data processing method. In: Bioinformatics. 2009 ; Vol. 25, No. 6. pp. 808-814.
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