@inproceedings{de97b947036e403bb84fab09b1082a5a,
title = "A novel concept for protein microarray: Land-contrast BioCD",
abstract = "We present a new type of protein microarray called the Land-contrast (LC) BioCD in which imaging contrast is induced by a patterned substrate rather than by patterned protein. This is realized by etching spot patterns in a silicon wafer. On the spot region the silicon dioxide thickness is 140 nm and on the land it is 77 nm. The spot and the land have equal reflectance but opposite interferometric quadrature responses for protein layer. Protein is evenly immobilized on the entire chip and detected by reflectometry. Therefore there is no need for protein printing, nor spectrometers, nor high angles nor polarization control to image the surface-bound protein. The LC BioCD can facilitate research on protein microarrays.",
keywords = "BioCD, Label-free, Land contrast, Optical biosensor, Protein microarray",
author = "Xuefeng Wang and Ming Zhao and Nolte, {David D.}",
year = "2009",
month = sep,
day = "18",
doi = "10.1117/12.809358",
language = "English (US)",
isbn = "9780819474162",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Design and Quality for Biomedical Technologies II",
note = "Design and Quality for Biomedical Technologies II ; Conference date: 26-01-2009 Through 26-01-2009",
}