A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations

Muhammad Ayaz, Justin Dietrich, Christopher Hulme

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

This Letter reveals an innovative and facile procedure to prepare quinoxalines in two synthetic steps. The microwave assisted Petasis reaction is followed by the acid mediated unmasking of an internal amino nucleophile, cyclodehydration and oxidation to give collections of quinoxalines in good to excellent yields.

Original languageEnglish (US)
Pages (from-to)4821-4823
Number of pages3
JournalTetrahedron Letters
Volume52
Issue number38
DOIs
StatePublished - Sep 21 2011

Fingerprint

Quinoxalines
Nucleophiles
Microwaves
Oxidation
Acids

Keywords

  • Intramolecular cyclization
  • Microwave
  • Multicomponent reaction
  • Petasis reaction
  • Quinoxaline

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations. / Ayaz, Muhammad; Dietrich, Justin; Hulme, Christopher.

In: Tetrahedron Letters, Vol. 52, No. 38, 21.09.2011, p. 4821-4823.

Research output: Contribution to journalArticle

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