A pilot sweet cherry feeding study in overweight men: Tolerance, safety, and anthocyanin exposure

Ashley J. Vargas, Lindsey N. McDonnell, Zhongfa Liu, Betsy C. Wertheim, Cynthia Thomson, Patricia A. Thompson

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Sweet cherries are rich in bioactive anthocyanins (ACN) and thus are considered a functional food. Yet, tolerance to and bioavailability of a significant daily dose of cherries has not been evaluated in humans. This pilot study aimed to assess compliance, tolerance, safety, and change in circulating/excreted ACNs due to daily consumption of sweet cherries. Change in bowel habits, quality of life, urinary/circulating concentration ACNs, and inflammatory biomarkers were measured in overweight, older men (n = 37) before and after daily consumption of three cups of sweet cherries for 4 weeks. Cherry fruit ACN content was also measured. Tolerance to intervention was high in this study. An increase in several plasma/urine ACNs was observed, but did not correlate with the amount of ACN measured in the fruits. No significant changes in inflammatory biomarkers were observed. This intervention was feasible and increased anthocyanin exposure in overweight men.

Original languageEnglish (US)
Pages (from-to)500-508
Number of pages9
JournalJournal of Functional Foods
Volume11
Issue numberC
DOIs
StatePublished - 2014

Fingerprint

Anthocyanins
Prunus avium
anthocyanins
Safety
Fruit
biomarkers
Biomarkers
Functional Food
fruits
quality of life
compliance
functional foods
Biological Availability
Compliance
Habits
bioavailability
urine
Quality of Life
Urine
dosage

Keywords

  • Anthocyanin
  • Biological marker
  • Cherry
  • Food safety
  • Prunus
  • Tolerance

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

A pilot sweet cherry feeding study in overweight men : Tolerance, safety, and anthocyanin exposure. / Vargas, Ashley J.; McDonnell, Lindsey N.; Liu, Zhongfa; Wertheim, Betsy C.; Thomson, Cynthia; Thompson, Patricia A.

In: Journal of Functional Foods, Vol. 11, No. C, 2014, p. 500-508.

Research output: Contribution to journalArticle

Vargas, Ashley J. ; McDonnell, Lindsey N. ; Liu, Zhongfa ; Wertheim, Betsy C. ; Thomson, Cynthia ; Thompson, Patricia A. / A pilot sweet cherry feeding study in overweight men : Tolerance, safety, and anthocyanin exposure. In: Journal of Functional Foods. 2014 ; Vol. 11, No. C. pp. 500-508.
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