@inproceedings{91ad93bacb8c498995fc19f700fe552b,
title = "A plasma lithography microengineered assay for studying architecture dependent wound healing of endothelial cells",
abstract = "A plasma lithography microengineered wound healing assay is developed to study architecture and injury dependences of endothelial cell migration. We study the migration of endothelial cell monolayers with dimensions from single cell width to millimeters mimicking various cardiovascular structures. Furthermore, we investigate the role of mechanical injury using wound healing assays that introduce different degrees of cell injury. Remarkably, the endothelial migration rate is robustly maintained in various circumstances: line patterns with different widths and different levels of mechanical injury. Our results also reveal that the number of leader cells, which guide the healing process, is proportional to the width of the structure suggesting a novel multicellular mechanism for regulating the endothelial wound healing process.",
keywords = "Architecture dependence, Cell injury, Endothelial cell, Plasma lithography, Wound healing",
author = "Yongliang Yang and Wong, {Pak Kin}",
year = "2011",
month = dec,
day = "1",
language = "English (US)",
isbn = "9781618395955",
series = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
pages = "326--328",
booktitle = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
note = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 ; Conference date: 02-10-2011 Through 06-10-2011",
}