A porcine model for fixed drug eruptions in humans: The case of antipyrine in the Yucatan micropig

Yvonne Pak, Kathleen Stollberg-Zagar, Michael Mayersohn

Research output: Contribution to journalArticle

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Abstract

To date, there is no acceptable animal model to investigate fixed drug eruptions (FDEs) in humans. We briefly report here observations suggesting that the Yucatan micropig may be a useful animal model for that purpose. During an investigation of antipyrine absorption and disposition, we observed the development of FDEs after intravenous administration of a 1 g dose. Our observations were consistent with those reported in several investigations of humans taking a single dose of antipyrine. To confirm these results, a naïve micropig was challenged. A male uncastrated Yucatan micropig (27.2 kg) was given a 1 g dose of antipyrine intravenously. After 30 days, this pig was rechallenged with the same intravenous dose of antipyrine (1 g). Blood samples were obtained to examine immunological endpoints. During the initial challenge, a fluid plaque (ca. 1-1.5 cm) appeared on the left hip of the pig ca. 6 h after dosing. After the rechallenge, inflamed pink patches were observed at the same sites where the blisters formed initially; however, no blisters re-formed. Changes of neutrophil, lymphocyte and eosinophil levels from baseline were noted 8 h after challenge. The micropig did not seem otherwise affected by the FDEs. These observations suggest that the Yucatan micropig, or swine in general, may be a useful animal model for detecting drugs that may cause FDEs in humans.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalJournal of Applied Toxicology
Volume26
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

Drug Eruptions
Antipyrine
Swine
Animal Models
Blister
Animals
Pharmaceutical Preparations
Eosinophils
Intravenous Administration
Lymphocytes
Hip
Neutrophils
Blood
Fluids

Keywords

  • Animal model
  • Cutaneous reactions

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

A porcine model for fixed drug eruptions in humans : The case of antipyrine in the Yucatan micropig. / Pak, Yvonne; Stollberg-Zagar, Kathleen; Mayersohn, Michael.

In: Journal of Applied Toxicology, Vol. 26, No. 1, 01.2006, p. 1-4.

Research output: Contribution to journalArticle

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