A potent and highly selective sulfotransferase inhibitor

Eli Chapman, Sheng Ding, Peter G. Schultz, Chi Huey Wong

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

In the present work, we have used a newly developed, fluorescence-based assay to screen a library of >30000 compounds as potential β-arylsulfotransferase-IV inhibitors. A total of 11 inhibitors were discovered. Most of the compounds discovered showed low micromolar inhibition, but one of the compounds showed potent inhibition (Ki = 96 nM). The most potent of these inhibitors was tested against a variety of other purine binding enzymes and showed remarkable specificity.

Original languageEnglish (US)
Pages (from-to)14524-14525
Number of pages2
JournalJournal of the American Chemical Society
Volume124
Issue number49
DOIs
StatePublished - Dec 11 2002
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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