A preliminary fluorodeoxyglucose positron emission tomography study in healthy adults reportinq dream-enactment behavior

Richard J. Caselli, Kewei Chen, Dan Bandy, Oded Smilovici, Bradley F. Boeve, David Osborne, Gene E. Alexander, James M. Parish, Lois E. Krahn, Eric M. Reiman

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Study Objectives: To test the hypothesis that healthy adults reporting dream-enactment behavior (DEB+) have reduced cerebral metabolic rate for glucose (CMRgI) in regions preferentially affected in patients with dementia with Lewy bodies (DLB). Design: Automated brain-mapping algorithms were used to compare regional fluorodeoxyglucose (FDG) positron emission tomography (PET) measurements from previously evaluated DEB cases and controls. Setting: Tertiary-care academic medical centers. Participants: Seventeen cognitively normal patients with DEB+ and 17 control subjects (DEB-) who were individually matched for age (59 ± 11 years), education level (16 ± 4 years), sex (67% women), body mass index (26 ± 4.8 kg/m2), first-degree relative with dementia (85%), and proportion of apolipoprotein E (APOE) e4 carriers (13 e4 carriers, 4 noncarriers). Interventions: FDG-PET. Measurements and Results: DEB was associated with significantly lower CMRgI in several brain regions known to be preferentially affected in both DLB and Alzheimer disease (parietal, temporal, and posterior cingulate cortexes) and in several other regions, including the anterior cingulate cortex (p < .001, uncorrected for multiple comparisons). The DEB-associated CMRgI reductions were significantly greater in the APOE e4 noncarriers than in the carriers. Conclusions: These preliminary findings suggest that cognitively normal persons with DEB have reduced CMRgI in brain regions known to be metabolically affected by DLB, supporting further study of DEB as a possible risk factor for the development of DLB.

Original languageEnglish (US)
Pages (from-to)927-933
Number of pages7
JournalSleep
Volume29
Issue number7
StatePublished - Jul 1 2006

Fingerprint

Lewy Body Disease
Positron-Emission Tomography
Apolipoprotein E4
Gyrus Cinguli
Apolipoproteins E
Dementia
Brain Mapping
Brain
Tertiary Healthcare
Alzheimer Disease
Body Mass Index
Education
Glucose

Keywords

  • Dementia with Lewy bodies
  • Preclinical dementia
  • REM sleep behavior disorder

ASJC Scopus subject areas

  • Physiology

Cite this

Caselli, R. J., Chen, K., Bandy, D., Smilovici, O., Boeve, B. F., Osborne, D., ... Reiman, E. M. (2006). A preliminary fluorodeoxyglucose positron emission tomography study in healthy adults reportinq dream-enactment behavior. Sleep, 29(7), 927-933.

A preliminary fluorodeoxyglucose positron emission tomography study in healthy adults reportinq dream-enactment behavior. / Caselli, Richard J.; Chen, Kewei; Bandy, Dan; Smilovici, Oded; Boeve, Bradley F.; Osborne, David; Alexander, Gene E.; Parish, James M.; Krahn, Lois E.; Reiman, Eric M.

In: Sleep, Vol. 29, No. 7, 01.07.2006, p. 927-933.

Research output: Contribution to journalArticle

Caselli, RJ, Chen, K, Bandy, D, Smilovici, O, Boeve, BF, Osborne, D, Alexander, GE, Parish, JM, Krahn, LE & Reiman, EM 2006, 'A preliminary fluorodeoxyglucose positron emission tomography study in healthy adults reportinq dream-enactment behavior', Sleep, vol. 29, no. 7, pp. 927-933.
Caselli RJ, Chen K, Bandy D, Smilovici O, Boeve BF, Osborne D et al. A preliminary fluorodeoxyglucose positron emission tomography study in healthy adults reportinq dream-enactment behavior. Sleep. 2006 Jul 1;29(7):927-933.
Caselli, Richard J. ; Chen, Kewei ; Bandy, Dan ; Smilovici, Oded ; Boeve, Bradley F. ; Osborne, David ; Alexander, Gene E. ; Parish, James M. ; Krahn, Lois E. ; Reiman, Eric M. / A preliminary fluorodeoxyglucose positron emission tomography study in healthy adults reportinq dream-enactment behavior. In: Sleep. 2006 ; Vol. 29, No. 7. pp. 927-933.
@article{df85b335e03b40e8b808e945a8cdae51,
title = "A preliminary fluorodeoxyglucose positron emission tomography study in healthy adults reportinq dream-enactment behavior",
abstract = "Study Objectives: To test the hypothesis that healthy adults reporting dream-enactment behavior (DEB+) have reduced cerebral metabolic rate for glucose (CMRgI) in regions preferentially affected in patients with dementia with Lewy bodies (DLB). Design: Automated brain-mapping algorithms were used to compare regional fluorodeoxyglucose (FDG) positron emission tomography (PET) measurements from previously evaluated DEB cases and controls. Setting: Tertiary-care academic medical centers. Participants: Seventeen cognitively normal patients with DEB+ and 17 control subjects (DEB-) who were individually matched for age (59 ± 11 years), education level (16 ± 4 years), sex (67{\%} women), body mass index (26 ± 4.8 kg/m2), first-degree relative with dementia (85{\%}), and proportion of apolipoprotein E (APOE) e4 carriers (13 e4 carriers, 4 noncarriers). Interventions: FDG-PET. Measurements and Results: DEB was associated with significantly lower CMRgI in several brain regions known to be preferentially affected in both DLB and Alzheimer disease (parietal, temporal, and posterior cingulate cortexes) and in several other regions, including the anterior cingulate cortex (p < .001, uncorrected for multiple comparisons). The DEB-associated CMRgI reductions were significantly greater in the APOE e4 noncarriers than in the carriers. Conclusions: These preliminary findings suggest that cognitively normal persons with DEB have reduced CMRgI in brain regions known to be metabolically affected by DLB, supporting further study of DEB as a possible risk factor for the development of DLB.",
keywords = "Dementia with Lewy bodies, Preclinical dementia, REM sleep behavior disorder",
author = "Caselli, {Richard J.} and Kewei Chen and Dan Bandy and Oded Smilovici and Boeve, {Bradley F.} and David Osborne and Alexander, {Gene E.} and Parish, {James M.} and Krahn, {Lois E.} and Reiman, {Eric M.}",
year = "2006",
month = "7",
day = "1",
language = "English (US)",
volume = "29",
pages = "927--933",
journal = "Sleep",
issn = "0161-8105",
publisher = "American Academy of Sleep Medicine",
number = "7",

}

TY - JOUR

T1 - A preliminary fluorodeoxyglucose positron emission tomography study in healthy adults reportinq dream-enactment behavior

AU - Caselli, Richard J.

AU - Chen, Kewei

AU - Bandy, Dan

AU - Smilovici, Oded

AU - Boeve, Bradley F.

AU - Osborne, David

AU - Alexander, Gene E.

AU - Parish, James M.

AU - Krahn, Lois E.

AU - Reiman, Eric M.

PY - 2006/7/1

Y1 - 2006/7/1

N2 - Study Objectives: To test the hypothesis that healthy adults reporting dream-enactment behavior (DEB+) have reduced cerebral metabolic rate for glucose (CMRgI) in regions preferentially affected in patients with dementia with Lewy bodies (DLB). Design: Automated brain-mapping algorithms were used to compare regional fluorodeoxyglucose (FDG) positron emission tomography (PET) measurements from previously evaluated DEB cases and controls. Setting: Tertiary-care academic medical centers. Participants: Seventeen cognitively normal patients with DEB+ and 17 control subjects (DEB-) who were individually matched for age (59 ± 11 years), education level (16 ± 4 years), sex (67% women), body mass index (26 ± 4.8 kg/m2), first-degree relative with dementia (85%), and proportion of apolipoprotein E (APOE) e4 carriers (13 e4 carriers, 4 noncarriers). Interventions: FDG-PET. Measurements and Results: DEB was associated with significantly lower CMRgI in several brain regions known to be preferentially affected in both DLB and Alzheimer disease (parietal, temporal, and posterior cingulate cortexes) and in several other regions, including the anterior cingulate cortex (p < .001, uncorrected for multiple comparisons). The DEB-associated CMRgI reductions were significantly greater in the APOE e4 noncarriers than in the carriers. Conclusions: These preliminary findings suggest that cognitively normal persons with DEB have reduced CMRgI in brain regions known to be metabolically affected by DLB, supporting further study of DEB as a possible risk factor for the development of DLB.

AB - Study Objectives: To test the hypothesis that healthy adults reporting dream-enactment behavior (DEB+) have reduced cerebral metabolic rate for glucose (CMRgI) in regions preferentially affected in patients with dementia with Lewy bodies (DLB). Design: Automated brain-mapping algorithms were used to compare regional fluorodeoxyglucose (FDG) positron emission tomography (PET) measurements from previously evaluated DEB cases and controls. Setting: Tertiary-care academic medical centers. Participants: Seventeen cognitively normal patients with DEB+ and 17 control subjects (DEB-) who were individually matched for age (59 ± 11 years), education level (16 ± 4 years), sex (67% women), body mass index (26 ± 4.8 kg/m2), first-degree relative with dementia (85%), and proportion of apolipoprotein E (APOE) e4 carriers (13 e4 carriers, 4 noncarriers). Interventions: FDG-PET. Measurements and Results: DEB was associated with significantly lower CMRgI in several brain regions known to be preferentially affected in both DLB and Alzheimer disease (parietal, temporal, and posterior cingulate cortexes) and in several other regions, including the anterior cingulate cortex (p < .001, uncorrected for multiple comparisons). The DEB-associated CMRgI reductions were significantly greater in the APOE e4 noncarriers than in the carriers. Conclusions: These preliminary findings suggest that cognitively normal persons with DEB have reduced CMRgI in brain regions known to be metabolically affected by DLB, supporting further study of DEB as a possible risk factor for the development of DLB.

KW - Dementia with Lewy bodies

KW - Preclinical dementia

KW - REM sleep behavior disorder

UR - http://www.scopus.com/inward/record.url?scp=33745714307&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745714307&partnerID=8YFLogxK

M3 - Article

C2 - 16895260

AN - SCOPUS:33745714307

VL - 29

SP - 927

EP - 933

JO - Sleep

JF - Sleep

SN - 0161-8105

IS - 7

ER -