A prospective randomized study of acyclovir versus ganciclovir plus human immune globulin prophylaxis of cytomegalovirus infection after solid organ transplantation

David L. Dunn, Kristen J. Gillingham, Marie A. Kramer, Walter J. Schmidt, Alejo Erice, Henry H. Balfour, Paul F. Gores, Rainer W.G. Gruessner, Arthur J. Matas, William D. Payne, David E.R. Sutherland, John S. Najarian

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70 Scopus citations

Abstract

Cytomegalovirus disease occurs frequently after solid organ transplantation and has been associated with decreased patient and allograft survival. We hypothesized that CMV transmission or reactivation begins immediately or soon after transplantation, and that a short-duration ganciclovir (GCV*)-based regimen would obviate the need for long-term antiviral agent administration, perhaps serving to interdict CMV infection and disease as well as, or perhaps even more effectively than, a more prolonged, oral acyclovir (ACV)-based form of prophylaxis. A total of 311 patients were stratified according to allograft type, age, and presence or absence or diabetes mellitus, and were then randomized to receive either long-duration ACV prophylaxis (800 mg orally or 400 mg i.v. q.i.d. fo.

Original languageEnglish (US)
Pages (from-to)876-884
Number of pages9
JournalTransplantation
Volume57
Issue number6
StatePublished - Mar 1994

ASJC Scopus subject areas

  • Transplantation

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    Dunn, D. L., Gillingham, K. J., Kramer, M. A., Schmidt, W. J., Erice, A., Balfour, H. H., Gores, P. F., Gruessner, R. W. G., Matas, A. J., Payne, W. D., Sutherland, D. E. R., & Najarian, J. S. (1994). A prospective randomized study of acyclovir versus ganciclovir plus human immune globulin prophylaxis of cytomegalovirus infection after solid organ transplantation. Transplantation, 57(6), 876-884.