A putative role for apelin in the etiology of obesity

Srujana Rayalam, Mary Anne Della-Fera, Paul A Krieg, Christopher M. Cox, Allan Robins, Clifton A. Baile

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Apelin, the endogenous ligand of the G protein-coupled APJ receptor has been shown to promote tumor angiogenesis. However, the effect of apelin on inducing angiogenesis in adipose tissue has not been investigated. In this review, we propose a putative role for apelin in promoting angiogenesis in adipose tissue. We further propose that targeting adipose tissue vasculature by blocking apelin signaling with anti-apelin antibodies will lead not only to inhibition of angiogenesis in adipose tissue but also to decreased adiposity.

Original languageEnglish (US)
Pages (from-to)815-819
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume368
Issue number3
DOIs
Publication statusPublished - Apr 11 2008

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Keywords

  • Adipose tissue
  • Adiposity
  • Angiogenesis
  • Apelin
  • APJ receptor
  • Endothelial cells
  • Obesity

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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