A quantitative light- and elecron-microscopic study of type IV nuclear bodies in crescentic glomerulonephritis

A. R. Graham, C. M. Payne, Raymond B Nagle

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Abstract

Type IV nuclear bodies were found in all renal biopsies obtained from 14 patients with crescentic glomerulonephritis (CGN) and in 8 of 43 control patients studied by light and electron microscopy. The mean ratio of Type IV nuclear bodies per 100 tubular cross-sections examined was 0.67±0.27 for the CGN cases, which was significantly different from 0.09±0.26 obtained for the controls (p < 0.05). Type IV nuclear bodies were most commonly seen in the epithelial cells of proximal tubules but were also seen occasionally in interstitial fibroblasts and cells of a collecting duct and a developing crescent.

Original languageEnglish (US)
Pages (from-to)359-366
Number of pages8
JournalAmerican Journal of Pathology
Volume102
Issue number3
StatePublished - 1981

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Glomerulonephritis
Light
Electron Microscopy
Fibroblasts
Epithelial Cells
Kidney
Biopsy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

A quantitative light- and elecron-microscopic study of type IV nuclear bodies in crescentic glomerulonephritis. / Graham, A. R.; Payne, C. M.; Nagle, Raymond B.

In: American Journal of Pathology, Vol. 102, No. 3, 1981, p. 359-366.

Research output: Contribution to journalArticle

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