Thermal conductivity detection (TCD) in conjunction with gas-liquid chromatography was employed for the analysis of enflurane in n-heptane extracts of whole blood. Enflurane was estimated to be 98 per cent extracted from whole blood by n-heptane. Analysis of enflurane standards ranging in concentration from 4.1 to 813 μM demonstrated linearity, with a correlation coefficient of 0.9999. As little as 8 μM enflurane may be detected in whole blood. TCD gas-liquid chromatography is a rapid and sensitive method for quantifying enflurane in whole blood.
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine