A regioselective and high-yielding method for formaldehyde inclusion in the 3CC Groebke-Blackburn-Bienaymé reaction: One-step access to 3-aminoimidazoazines

Anuj Sharma, Hong Yu Li

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

A regioselective, mild, convenient, and effective condition is developed for the inclusion of glyoxylic acid as formaldehyde equivalent in the 3CC reaction towards synthesis of 3-aminoalkyl imidazo-azines. In general, formaldehydes do not perform well with Ugi-type multicomponent sequences, and the method reported here is a regioselective and high-yielding one for the HCHO variant of Groebke-Blackburn-Bienaymé reaction.

Original languageEnglish (US)
Article numberS00811ST
Pages (from-to)1407-1412
Number of pages6
JournalSynlett
Issue number10
DOIs
StatePublished - May 18 2011

Keywords

  • Groebke-Blackburn-Bienaymé
  • aminoimidazoazines
  • formaldehyde
  • glyoxylic acid
  • multicomponent reaction

ASJC Scopus subject areas

  • Organic Chemistry

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