A relationship between substance P receptor and retinal fibers in the rat suprachiasmatic nucleus

Koichi Takatsuji, Emiko Senba, Patrick W Mantyh, Masaya Tohyama

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The suprachiasmatic nucleus (SCN) in the hypothalamus controls many of the circadian rhythms in mammalian species. In the present study, we investigated the location of substance P receptor (SPR)-containing neurons in the rat SCN, using a specific antibody against SPR, which corresponds to the NK-1 subtype of tachykinin receptors, and also examined the synaptic relationship between SPR-containing neurons and retinal fibers at the ultrastructural level. An SPR-immunoreactive meshwork of labeled somata and dendrites was identified in the SCN. The strongest SPR-immunoreactivity was observed in the dorsal and lateral parts of the SCN. Many labeled somata were identified there and their dendrites protruded ventrally from their somata. A few SPR-immunoreactive somata were observed also in the ventral part of the SCN and within the optic tract. In the SCN of eye-enucleated animals, degenerating retinal fibers were shown to terminate on SPR-immunoreactive dendrites forming asymmetrical axo-dendritic contacts.

Original languageEnglish (US)
Pages (from-to)53-61
Number of pages9
JournalBrain Research
Volume698
Issue number1-2
DOIs
StatePublished - Nov 6 1995
Externally publishedYes

Fingerprint

Neurokinin-1 Receptors
Suprachiasmatic Nucleus
Carisoprodol
Dendrites
Retinal Neurons
Circadian Rhythm
Hypothalamus
Neurons
Antibodies

Keywords

  • Immunohistochemistry
  • Rat
  • Retinal fiber
  • Retinohypothalamic projection
  • Substance P receptor
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

A relationship between substance P receptor and retinal fibers in the rat suprachiasmatic nucleus. / Takatsuji, Koichi; Senba, Emiko; Mantyh, Patrick W; Tohyama, Masaya.

In: Brain Research, Vol. 698, No. 1-2, 06.11.1995, p. 53-61.

Research output: Contribution to journalArticle

Takatsuji, Koichi ; Senba, Emiko ; Mantyh, Patrick W ; Tohyama, Masaya. / A relationship between substance P receptor and retinal fibers in the rat suprachiasmatic nucleus. In: Brain Research. 1995 ; Vol. 698, No. 1-2. pp. 53-61.
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