A removable silicone elastomer seal reduces granulation tissue growth and maintains the sterility of recording chambers for primate neurophysiology

Kevin M. Spitler, Katalin M. Gothard

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The maintenance of the sterility of craniotomies for serial acute neurophysiological recordings is exacting and time consuming yet is vital to the health of valuable experimental animals. We have developed a method to seal the craniotomy with surgical grade silicone elastomer (Silastic®) in a hermetically sealed chamber. Under these conditions the tissues in the craniotomy and the inside surface of the chamber remain unpopulated by bacteria. The silicone elastomer sealant retarded the growth of granulation tissue on the dura and reduced the procedures required to maintain ideal conditions for neurophysiological recordings.

Original languageEnglish (US)
Pages (from-to)23-26
Number of pages4
JournalJournal of Neuroscience Methods
Volume169
Issue number1
DOIs
StatePublished - Mar 30 2008

Keywords

  • Craniotomy
  • Dura mater
  • Granulation tissue
  • Monkey
  • Neurophysiology
  • Silastic
  • Silicone elastomer

ASJC Scopus subject areas

  • Neuroscience(all)

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