A review of responsive MRI contrast agents: 2005-2014

Dina V. Hingorani, Adam S. Bernstein, Mark "Marty" Pagel

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

This review focuses on MRI contrast agents that are responsive to a change in a physiological biomarker. The response mechanisms are dependent on six physicochemical characteristics, including the accessibility of water to the agent, tumbling time, proton exchange rate, electron spin state, MR frequency or superparamagnetism of the agent. These characteristics can be affected by changes in concentrations or activities of enzymes, proteins, nucleic acids, metabolites, or metal ions, or changes in redox state, pH, temperature, or light. A total of 117 examples are presented, including ones that employ nuclei other than <sup>1</sup>H, which attests to the creativity of multidisciplinary research efforts to develop responsive MRI contrast agents.

Original languageEnglish (US)
Pages (from-to)245-265
Number of pages21
JournalContrast Media and Molecular Imaging
Volume10
Issue number4
DOIs
StatePublished - Jul 1 2015

Fingerprint

Contrast Media
Creativity
Nucleic Acids
Oxidation-Reduction
Protons
Biomarkers
Metals
Electrons
Ions
Light
Temperature
Water
Enzymes
Research
Proteins

Keywords

  • agents
  • CEST agents
  • Hyperpolarized agents
  • MRI contrast agents
  • MRS agents
  • Responsive agents
  • T<inf>1</inf> agents
  • T<inf>2</inf>

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

A review of responsive MRI contrast agents : 2005-2014. / Hingorani, Dina V.; Bernstein, Adam S.; Pagel, Mark "Marty".

In: Contrast Media and Molecular Imaging, Vol. 10, No. 4, 01.07.2015, p. 245-265.

Research output: Contribution to journalArticle

Hingorani, Dina V. ; Bernstein, Adam S. ; Pagel, Mark "Marty". / A review of responsive MRI contrast agents : 2005-2014. In: Contrast Media and Molecular Imaging. 2015 ; Vol. 10, No. 4. pp. 245-265.
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