A role for parathyroid hormone-related protein in the pathogenesis of inflammatory/autoimmune diseases

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Our increased understanding of the critical role of cytokines in chronic inflammatory/autoimmune diseases has led to the recent development of effective anti-cytokine treatments. In particular, agents blocking the function of TNF-α, a cytokine first identified as an endotoxin-inducible mediator of tumor cell necrosis, are now licensed for the treatment of rheumatoid arthritis (RA) and inflammatory bowel disease. However, TNF-α is but one member of a cytokine network that is responsible for mediating these inflammatory disorders. Therefore, as our understanding of the pathophysiologic role of other members of this inflammatory network increases, other cytokines may similarly be identified as effective targets for treatment. In this article, we will review evidence which suggests that parathyroid hormone-related protein (PTHrP), a peptide which, like TNF-α, was first identified because of its effects in the setting of malignancy, may in fact serve an important non-neoplastic, physiologic function by mediating the inflammatory/autoimmune host response. Data identifying PTHrP as a member of the cytokine network induced in multi-organ inflammation and rheumatoid arthritis will be summarized, initial evidence comparing the therapeutic efficacy of PTHrP- vs. TNF-α-blockade in the treatment of endotoxemia will be reviewed, and potential future areas of research, including assessment of the effects of PTHrP blockade in the treatment of RA, will be discussed.

Original languageEnglish (US)
Pages (from-to)1101-1121
Number of pages21
JournalInternational Immunopharmacology
Volume1
Issue number6
DOIs
StatePublished - Jun 2001

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Parathyroid Hormone-Related Protein
Autoimmune Diseases
Cytokines
Rheumatoid Arthritis
Endotoxemia
Autoimmunity
Inflammatory Bowel Diseases
Endotoxins
Neoplasms
Necrosis
Inflammation
Peptides
Research

Keywords

  • Endotoxin
  • PTHrP
  • Rheumatoid arthritis
  • TNF-α

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

A role for parathyroid hormone-related protein in the pathogenesis of inflammatory/autoimmune diseases. / Funk, Janet L.

In: International Immunopharmacology, Vol. 1, No. 6, 06.2001, p. 1101-1121.

Research output: Contribution to journalArticle

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