A shifting paradigm

Histone deacetylases and transcriptional activation

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Transcriptional repression and silencing have been strongly associated with hypoacetylation of histones. Accordingly, histone deacetylases, which remove acetyl groups from histones, have been shown to participate in mechanisms of transcriptional repression. Therefore, current models of the role of acetylation in transcriptional regulation focus on the acetylation status of histones and designate histone acetyltransferases, which add acetyl groups to histones, as transcriptional coactivators and histone deacetylases as corepressors. In recent years, an accumulation of studies have shown that these enzymes also target non-histone proteins and that histone deacetylases have clear roles as coactivators at a variety of genes, some of which are key regulators of cell growth and survival. This review summarizes the evidence for histone deacetylases as coactivators and provides models of coactivation mechanisms, some of which integrate roles of acetylated histones and non-histone proteins in transcription.

Original languageEnglish (US)
Pages (from-to)15-24
Number of pages10
JournalBioEssays
Volume30
Issue number1
DOIs
StatePublished - Jan 2008

Fingerprint

Histone Deacetylases
transcriptional activation
histones
Histones
Transcriptional Activation
Chemical activation
Acetylation
Histone Acetyltransferases
Co-Repressor Proteins
acetylation
Cell growth
Transcription
Cell Survival
Proteins
Genes
Enzymes
Growth
cell viability
cell growth
proteins

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

A shifting paradigm : Histone deacetylases and transcriptional activation. / Smith, Catharine.

In: BioEssays, Vol. 30, No. 1, 01.2008, p. 15-24.

Research output: Contribution to journalArticle

@article{736a7fe7f7974eb59956aba7edca00e8,
title = "A shifting paradigm: Histone deacetylases and transcriptional activation",
abstract = "Transcriptional repression and silencing have been strongly associated with hypoacetylation of histones. Accordingly, histone deacetylases, which remove acetyl groups from histones, have been shown to participate in mechanisms of transcriptional repression. Therefore, current models of the role of acetylation in transcriptional regulation focus on the acetylation status of histones and designate histone acetyltransferases, which add acetyl groups to histones, as transcriptional coactivators and histone deacetylases as corepressors. In recent years, an accumulation of studies have shown that these enzymes also target non-histone proteins and that histone deacetylases have clear roles as coactivators at a variety of genes, some of which are key regulators of cell growth and survival. This review summarizes the evidence for histone deacetylases as coactivators and provides models of coactivation mechanisms, some of which integrate roles of acetylated histones and non-histone proteins in transcription.",
author = "Catharine Smith",
year = "2008",
month = "1",
doi = "10.1002/bies.20687",
language = "English (US)",
volume = "30",
pages = "15--24",
journal = "BioEssays",
issn = "0265-9247",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - A shifting paradigm

T2 - Histone deacetylases and transcriptional activation

AU - Smith, Catharine

PY - 2008/1

Y1 - 2008/1

N2 - Transcriptional repression and silencing have been strongly associated with hypoacetylation of histones. Accordingly, histone deacetylases, which remove acetyl groups from histones, have been shown to participate in mechanisms of transcriptional repression. Therefore, current models of the role of acetylation in transcriptional regulation focus on the acetylation status of histones and designate histone acetyltransferases, which add acetyl groups to histones, as transcriptional coactivators and histone deacetylases as corepressors. In recent years, an accumulation of studies have shown that these enzymes also target non-histone proteins and that histone deacetylases have clear roles as coactivators at a variety of genes, some of which are key regulators of cell growth and survival. This review summarizes the evidence for histone deacetylases as coactivators and provides models of coactivation mechanisms, some of which integrate roles of acetylated histones and non-histone proteins in transcription.

AB - Transcriptional repression and silencing have been strongly associated with hypoacetylation of histones. Accordingly, histone deacetylases, which remove acetyl groups from histones, have been shown to participate in mechanisms of transcriptional repression. Therefore, current models of the role of acetylation in transcriptional regulation focus on the acetylation status of histones and designate histone acetyltransferases, which add acetyl groups to histones, as transcriptional coactivators and histone deacetylases as corepressors. In recent years, an accumulation of studies have shown that these enzymes also target non-histone proteins and that histone deacetylases have clear roles as coactivators at a variety of genes, some of which are key regulators of cell growth and survival. This review summarizes the evidence for histone deacetylases as coactivators and provides models of coactivation mechanisms, some of which integrate roles of acetylated histones and non-histone proteins in transcription.

UR - http://www.scopus.com/inward/record.url?scp=38049016277&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38049016277&partnerID=8YFLogxK

U2 - 10.1002/bies.20687

DO - 10.1002/bies.20687

M3 - Article

VL - 30

SP - 15

EP - 24

JO - BioEssays

JF - BioEssays

SN - 0265-9247

IS - 1

ER -