A silicon SPECT system for molecular imaging of the mouse brain

Sepideh Shokouhi, Mark A. Fritz, Benjamin S. McDonald, Heather L. Durko, Lars R Furenlid, Donald W. Wilson, Todd E. Peterson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

We previously demonstrated the feasibility of using silicon double-sided strip detectors (DSSDs) for SPECT imaging of the activity distribution of iodine-125 using a 300-micrometer thick detector. Based on this experience, we now have developed fully customized silicon DSSDs and associated readout electronics with the intent of developing a multi-pinhole SPECT system. Each DSSD has a 60.4 mm × 60.4 mm active area and is 1 mm thick. The strip pitch is 59 micrometers, and the readout of the 1024 strips on each side gives rise to a detector with over one million pixels. Combining four high-resolution DSSDs into a SPECT system offers an unprecedented space-bandwidth product for the imaging of single-photon emitters. The system consists of two camera heads with two silicon detectors stacked one behind the other in each head. The collimator has a focused pinhole system with cylindrical-shaped pinholes that are laser-drilled in a 250 μm tungsten plate. The unique ability to collect projection data at two magnifications simultaneously allows for multiplexed data at high resolution to be combined with lower magnification data with little or no multiplexing. With the current multi-pinhole collimator design, our SPECT system will be capable of offering high spatial resolution, sensitivity and angular sampling for small field-of-view applications, such as molecular imaging of the mouse brain.

Original languageEnglish (US)
Title of host publicationIEEE Nuclear Science Symposium Conference Record
Pages2782-2784
Number of pages3
Volume4
DOIs
StatePublished - 2007
Event2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC - Honolulu, HI, United States
Duration: Oct 27 2007Nov 3 2007

Other

Other2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC
CountryUnited States
CityHonolulu, HI
Period10/27/0711/3/07

Fingerprint

Molecular imaging
Brain
Detectors
Silicon
Imaging techniques
Silicon detectors
Iodine
Multiplexing
Tungsten
Electronic equipment
Photons
Pixels
Cameras
Sampling
Bandwidth
Lasers

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Industrial and Manufacturing Engineering

Cite this

Shokouhi, S., Fritz, M. A., McDonald, B. S., Durko, H. L., Furenlid, L. R., Wilson, D. W., & Peterson, T. E. (2007). A silicon SPECT system for molecular imaging of the mouse brain. In IEEE Nuclear Science Symposium Conference Record (Vol. 4, pp. 2782-2784). [4436717] https://doi.org/10.1109/NSSMIC.2007.4436717

A silicon SPECT system for molecular imaging of the mouse brain. / Shokouhi, Sepideh; Fritz, Mark A.; McDonald, Benjamin S.; Durko, Heather L.; Furenlid, Lars R; Wilson, Donald W.; Peterson, Todd E.

IEEE Nuclear Science Symposium Conference Record. Vol. 4 2007. p. 2782-2784 4436717.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shokouhi, S, Fritz, MA, McDonald, BS, Durko, HL, Furenlid, LR, Wilson, DW & Peterson, TE 2007, A silicon SPECT system for molecular imaging of the mouse brain. in IEEE Nuclear Science Symposium Conference Record. vol. 4, 4436717, pp. 2782-2784, 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS-MIC, Honolulu, HI, United States, 10/27/07. https://doi.org/10.1109/NSSMIC.2007.4436717
Shokouhi S, Fritz MA, McDonald BS, Durko HL, Furenlid LR, Wilson DW et al. A silicon SPECT system for molecular imaging of the mouse brain. In IEEE Nuclear Science Symposium Conference Record. Vol. 4. 2007. p. 2782-2784. 4436717 https://doi.org/10.1109/NSSMIC.2007.4436717
Shokouhi, Sepideh ; Fritz, Mark A. ; McDonald, Benjamin S. ; Durko, Heather L. ; Furenlid, Lars R ; Wilson, Donald W. ; Peterson, Todd E. / A silicon SPECT system for molecular imaging of the mouse brain. IEEE Nuclear Science Symposium Conference Record. Vol. 4 2007. pp. 2782-2784
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