A simple, cheap alternative to 'designer convertible isonitriles' expedited with microwaves

Christopher Hulme, Shashi Chappeta, Justin Dietrich

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Interest in designer convertible isonitriles has increased in recent years with the growing recognition that isonitrile-based multi-component reactions (IMCRs) are highly effective in rapidly accessing, new and pharmacologically relevant diversity space. This Letter reports on the novel use of n-butylisonitrile as a cheaper and more atom-economical alternative to currently reported 'designer convertible isonitriles', facilitated by the advent of microwave-assisted organic synthesis (MAOS).

Original languageEnglish (US)
Pages (from-to)4054-4057
Number of pages4
JournalTetrahedron Letters
Volume50
Issue number28
DOIs
StatePublished - Jul 15 2009

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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