A simple method for NMR t1 noise suppression

Huaping Mo, John S. Harwood, Danzhou Yang, Carol Beth Post

Research output: Research - peer-reviewArticle

Abstract

t1 noise appears as random or semi-random spurious streaks along the indirect t1 (F1) dimension of a 2D or nD NMR spectrum. It can significantly downgrade spectral quality, especially for spectra with strong diagonal signals such as NOESY, because useful and weak cross-peaks can be easily buried under t1 noise. One of the significant contributing factors to t1 noise is unwanted and semi-random F2 signal modulation during t1 acquisition. As such, t1 noise from different acquisitions is unlikely to correlate with each other strongly. In the case of NOESY, co-addition of multiple spectra significantly reduces t1 noise compared with conventional acquisition with the same amount of total acquisition time and resolution.

LanguageEnglish (US)
Pages43-50
Number of pages8
JournalJournal of Magnetic Resonance
Volume276
DOIs
StatePublished - Mar 1 2017
Externally publishedYes

Fingerprint

retarding
nuclear magnetic resonance
Nuclear magnetic resonance
Modulation
Noise
acquisition
random signals
modulation

Keywords

  • 2D spectroscopy
  • Frequency fluctuation
  • NMR
  • NOESY
  • t noise suppression

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics

Cite this

A simple method for NMR t1 noise suppression. / Mo, Huaping; Harwood, John S.; Yang, Danzhou; Post, Carol Beth.

In: Journal of Magnetic Resonance, Vol. 276, 01.03.2017, p. 43-50.

Research output: Research - peer-reviewArticle

Mo H, Harwood JS, Yang D, Post CB. A simple method for NMR t1 noise suppression. Journal of Magnetic Resonance. 2017 Mar 1;276:43-50. Available from, DOI: 10.1016/j.jmr.2016.12.014
Mo, Huaping ; Harwood, John S. ; Yang, Danzhou ; Post, Carol Beth. / A simple method for NMR t1 noise suppression. In: Journal of Magnetic Resonance. 2017 ; Vol. 276. pp. 43-50
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