A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoire

Baomei Wang, Tina M. Primeau, Nancy Myers, Henry W. Rohrs, Michael L. Gross, Lonnie Lybarger, Ted H. Hansen, Janet M. Connolly

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Pathogen recognition by T cells is dependent on their exquisite specificity for self-major histocompatibility complex (MHC) molecules presenting a bound peptide. Although this specificity results from positive and negative selection of developing T cells in the thymus, the relative contribution of these two processes remains controversial To address the relation between the selecting peptide-MHC complex and the specificity of mature T cells, we generated transgenic mice that express a single peptide-MHC class I complex. We demonstrate that positive selection of CD8 T cells in these mice results in an MHC-specific repertoire. Although selection on a single complex is peptide promiscuous, mature T cells are highly peptide specific. Thus, positive selection imparts MHC and peptide specificity on the peripheral CD8 T cell repertoire.

Original languageEnglish (US)
Pages (from-to)871-874
Number of pages4
JournalScience
Volume326
Issue number5954
DOIs
StatePublished - Nov 6 2009

ASJC Scopus subject areas

  • General

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    Wang, B., Primeau, T. M., Myers, N., Rohrs, H. W., Gross, M. L., Lybarger, L., Hansen, T. H., & Connolly, J. M. (2009). A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoire. Science, 326(5954), 871-874. https://doi.org/10.1126/science.1177627