A spin filter method for continuous evaluation of hemolysis

Fernando Alvarez-Núñez, Danielle A. Rosin, Samuel H. Yalkowsky

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A novel method for quantifying hemolysis is described. This method uses a spin filter to separate the free hemoglobin from the red blood cells suspended in the test solution. This procedure enables the use of a closed loop system that continuously measures hemolysis spectrophotometrically. It is shown that hemolysis does not always stop after the solution has been quenched with normal saline. In fact, the process of hemolysis induced by chemicals such as potassium oleate is relatively slow.

Original languageEnglish (US)
Pages (from-to)1041-1043
Number of pages3
JournalJournal of pharmaceutical sciences
Volume88
Issue number10
DOIs
StatePublished - Oct 1999

ASJC Scopus subject areas

  • Pharmaceutical Science

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