A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Roles in Human Medicine

Kevin A. Scott, M. Haziq Qureshi, Philip B. Cox, Christopher M. Marshall, Bailey C. Bellaire, Michael Wilcox, Bradey A.R. Stuart, Jon T. Njardarson

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

The FDA Green Book is a list of all drug products that have been approved by the FDA for use in veterinary medicine. The Green Book, as published, lacks structural information corresponding to approved drugs. To address this gap, we have compiled the structural data for all FDA Green Book drugs approved through the end of 2019. Herein we discuss the relevance of this data set to human drugs in the context of structural classes and physicochemical properties. Analysis reveals that physicochemical properties are highly optimized and consistent with a high probability of favorable drug metabolism and pharmacokinetic properties, including good oral bioavailability for most compounds. We provide a detailed analysis of this data set organized on the basis of structure and function. Slightly over half (51%) of vet drugs are also approved in human medicine. Combination drugs are biologics are also discussed.

Original languageEnglish (US)
Pages (from-to)15449-15482
Number of pages34
JournalJournal of Medicinal Chemistry
Volume63
Issue number24
DOIs
StatePublished - Dec 24 2020

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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