A Study of Lipid Biosynthesis in Cryptococcus Neoformans

Ineko Inoue, Fariba Mirbod, Mariko Seishima, Shunji Mori, Yoshinori Nozawa

Research output: Contribution to journalArticle

Abstract

Changes in incorporation of [14C] acetate into lipid fractions were examined in Cryptococcus neoformans during growth and were compared with those in Candida albicans. The uptake of [14C] acetate in the total lipids of Cr. neoformans gradually increased following the growth phase and then decreased at the stationary phase. The hydrolysis of triacylglycerol (TG), the main lipid in Cr. neoformans, was considered to be accelerated as the radioactivity in TG decreased with a concomitant increase of radioactivity in free fatty acid (FFA) in the stationary phase. In contrast, in C. albicans, phosphatidylcholine (PC), the major component of cell membrane, increased during the growth phase and decreased in the stationary phase. It was also observed that the biosynthesis of acidic phospholipids, PI and PS, was enhanced during the growth phase in both types of fungi.

Original languageEnglish (US)
Pages (from-to)421-427
Number of pages7
JournalNippon Ishinkin Gakkai Zasshi
Volume35
Issue number4
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Keywords

  • Candida albicans
  • Cryptococcus neoformans
  • lipid biosynthesis

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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