A Survey of the Structures of US FDA Approved Combination Drugs

Pradipta Das, Michael D. Delost, Munaum H. Qureshi, David T. Smith, Jon T Njardarson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Combination drugs are an important class of US FDA approved pharmaceuticals. These drugs have been on a continuous growth trajectory since the first combination drugs were approved in the 1940s. In this Perspective, we report the first comprehensive compilation and analysis of US FDA approved combination drugs, from the first approval in 1943 through 2018. Our database contains 419 combination drugs, which are represented by 328 unique small molecule structures. Breakdown of these drugs according to disease category, structure, combination composition, and year of approval is presented as well as the top 24 most commonly used small molecule combination drug components. For frequently used small molecule components, we present "relationship diagrams" to aid in the visualization of the many drug combinations these structures are part of. The main body contains 10 disease-focused sections wherein every small molecule component utilized as part of a combination for each disease category is displayed.

Original languageEnglish (US)
JournalJournal of Medicinal Chemistry
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Drug Combinations
Pharmaceutical Preparations
Drug Approval
Surveys and Questionnaires
Databases
Growth

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

A Survey of the Structures of US FDA Approved Combination Drugs. / Das, Pradipta; Delost, Michael D.; Qureshi, Munaum H.; Smith, David T.; Njardarson, Jon T.

In: Journal of Medicinal Chemistry, 01.01.2018.

Research output: Contribution to journalArticle

Das, Pradipta ; Delost, Michael D. ; Qureshi, Munaum H. ; Smith, David T. ; Njardarson, Jon T. / A Survey of the Structures of US FDA Approved Combination Drugs. In: Journal of Medicinal Chemistry. 2018.
@article{61b1bf8c83204141a27259534297e3d3,
title = "A Survey of the Structures of US FDA Approved Combination Drugs",
abstract = "Combination drugs are an important class of US FDA approved pharmaceuticals. These drugs have been on a continuous growth trajectory since the first combination drugs were approved in the 1940s. In this Perspective, we report the first comprehensive compilation and analysis of US FDA approved combination drugs, from the first approval in 1943 through 2018. Our database contains 419 combination drugs, which are represented by 328 unique small molecule structures. Breakdown of these drugs according to disease category, structure, combination composition, and year of approval is presented as well as the top 24 most commonly used small molecule combination drug components. For frequently used small molecule components, we present {"}relationship diagrams{"} to aid in the visualization of the many drug combinations these structures are part of. The main body contains 10 disease-focused sections wherein every small molecule component utilized as part of a combination for each disease category is displayed.",
author = "Pradipta Das and Delost, {Michael D.} and Qureshi, {Munaum H.} and Smith, {David T.} and Njardarson, {Jon T}",
year = "2018",
month = "1",
day = "1",
doi = "10.1021/acs.jmedchem.8b01610",
language = "English (US)",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",

}

TY - JOUR

T1 - A Survey of the Structures of US FDA Approved Combination Drugs

AU - Das, Pradipta

AU - Delost, Michael D.

AU - Qureshi, Munaum H.

AU - Smith, David T.

AU - Njardarson, Jon T

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Combination drugs are an important class of US FDA approved pharmaceuticals. These drugs have been on a continuous growth trajectory since the first combination drugs were approved in the 1940s. In this Perspective, we report the first comprehensive compilation and analysis of US FDA approved combination drugs, from the first approval in 1943 through 2018. Our database contains 419 combination drugs, which are represented by 328 unique small molecule structures. Breakdown of these drugs according to disease category, structure, combination composition, and year of approval is presented as well as the top 24 most commonly used small molecule combination drug components. For frequently used small molecule components, we present "relationship diagrams" to aid in the visualization of the many drug combinations these structures are part of. The main body contains 10 disease-focused sections wherein every small molecule component utilized as part of a combination for each disease category is displayed.

AB - Combination drugs are an important class of US FDA approved pharmaceuticals. These drugs have been on a continuous growth trajectory since the first combination drugs were approved in the 1940s. In this Perspective, we report the first comprehensive compilation and analysis of US FDA approved combination drugs, from the first approval in 1943 through 2018. Our database contains 419 combination drugs, which are represented by 328 unique small molecule structures. Breakdown of these drugs according to disease category, structure, combination composition, and year of approval is presented as well as the top 24 most commonly used small molecule combination drug components. For frequently used small molecule components, we present "relationship diagrams" to aid in the visualization of the many drug combinations these structures are part of. The main body contains 10 disease-focused sections wherein every small molecule component utilized as part of a combination for each disease category is displayed.

UR - http://www.scopus.com/inward/record.url?scp=85058147420&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058147420&partnerID=8YFLogxK

U2 - 10.1021/acs.jmedchem.8b01610

DO - 10.1021/acs.jmedchem.8b01610

M3 - Article

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

ER -