A synthetic method for unsymmetrical disulfides of cysteine: the bis-cysteine disulfide of meso-2,3-dimercaptosuccinic acid.

Robin Polt, Yushun Li, Quintus Fernando, Mario Rivera

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

meso-Dimercaptosuccinic acid (DMSA) is the drug of choice for the treatment of lead-poisoning. DMSA is excreted in the urine of lead-poisoned rabbits as a conjugate with two molecules of cysteine. To confirm this, and to examine the hypothesis that DMSA may be acting as a pro-drug, we have synthesized the DMSA-bis-disulfide using novel methodology based on the use of sulfenimides derived from cysteine.

Original languageEnglish (US)
Pages (from-to)2961-2964
Number of pages4
JournalTetrahedron Letters
Volume33
Issue number21
DOIs
StatePublished - May 19 1992

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'A synthetic method for unsymmetrical disulfides of cysteine: the bis-cysteine disulfide of meso-2,3-dimercaptosuccinic acid.'. Together they form a unique fingerprint.

  • Cite this