A system calibration and fast iterative reconstruction method for next-generation SPECT imagers

Brian W. Miller, Roel Van Holen, Harrison H Barrett, Lars R Furenlid

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Recently, high-resolution gamma cameras have been developed with detectors containing > 10 5-10 5 elements. Single-photon emission computed tomography (SPECT) imagers based on these detectors usually also have a large number of voxel bins and therefore face memory storage issues for the system matrix when performing fast tomographic reconstructions using iterative algorithms. To address these issues, we have developed a method that parameterizes the detector response to a point source and generates the system matrix on the fly during MLEM or OSEM on graphics hardware. The calibration method, interpolation of coefficient data, and reconstruction results are presented in the context of a recently commissioned small-animal SPECT imager, called FastSPECT III.

Original languageEnglish (US)
Article number6213168
Pages (from-to)1990-1996
Number of pages7
JournalIEEE Transactions on Nuclear Science
Volume59
Issue number5 PART 1
DOIs
StatePublished - 2012

Fingerprint

Single photon emission computed tomography
Image sensors
tomography
Calibration
Detectors
detectors
photons
Bins
matrices
Computer hardware
point sources
interpolation
animals
Interpolation
hardware
Animals
Cameras
cameras
Data storage equipment
high resolution

Keywords

  • Calibration
  • Graphics processing units (GPUs)
  • High-performance computing
  • Image reconstruction
  • Ordered-subset expectation maximization (OSEM)
  • Single-photon emission computed tomography (SPECT)
  • System matrix

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Nuclear Energy and Engineering
  • Nuclear and High Energy Physics

Cite this

A system calibration and fast iterative reconstruction method for next-generation SPECT imagers. / Miller, Brian W.; Van Holen, Roel; Barrett, Harrison H; Furenlid, Lars R.

In: IEEE Transactions on Nuclear Science, Vol. 59, No. 5 PART 1, 6213168, 2012, p. 1990-1996.

Research output: Contribution to journalArticle

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