A unique pair of monozygotic twins with concordant clear cell renal cell carcinoma: A case report

Min Han Tan, Jasmine Yang, Hwei Ling Tan, Chin Fong Wong, Puay Hoon Tan, Hong Gee Sim, Peter Ang, Chee Keong Toh, Miah Hiang Tay, Eileen Poon, Aik Seng Ooi, Bin Tean Teh

Research output: Contribution to journalArticle

Abstract

Introduction: Genetic predisposition to clear cell renal cell carcinoma (ccRCC) has been linked to disorders such as von Hippel-Lindau (VHL) syndrome. While twin research is a classic approach for elucidating genetic and environmental contributions to disease, no monozygotic twin-pair concordant for ccRCC in the absence of VHL syndrome has been previously reported in the literature or in major twin registries. Clinical Picture: We describe a unique monozygotic twin-pair concordant for ccRCC, with discordant but early ages of onset of 25 and 38 respectively. Cytogenetic studies and direct sequencing for VHL gene mutations in the second twin proved unremarkable. Conclusions: This is the first reported case of monozygotic twins concordant for ccRCC in the absence of VHL gene mutation. The early yet discordant, age of onset of disease in both twins suggests both genetic and environmental contributions to ccRCC.

Original languageEnglish (US)
Pages (from-to)61-63
Number of pages3
JournalAnnals of the Academy of Medicine Singapore
Volume39
Issue number1
StatePublished - Jan 1 2010
Externally publishedYes

Keywords

  • Gene-environment interaction
  • Kidney cancer
  • Von Hippel Lindau syndrome

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Tan, M. H., Yang, J., Tan, H. L., Wong, C. F., Tan, P. H., Sim, H. G., Ang, P., Toh, C. K., Tay, M. H., Poon, E., Ooi, A. S., & Teh, B. T. (2010). A unique pair of monozygotic twins with concordant clear cell renal cell carcinoma: A case report. Annals of the Academy of Medicine Singapore, 39(1), 61-63.