Aberrant hormone production from ovarian neoplasms: Strategies for diagnosis and therapy

Steven D. Leach, Annette I. LaMorte, Lawrence D. True, Stuart D Flynn, Peter E. Schwartz, C. Elton Cahow, Barbara K. Kinder

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Syndromes involving peptide or nonsex steroid hormone secretion due to aberrantly located tumors are rare. We report a collected series of 16 patients with ectopic hormone production from ovarian neoplasms, including 3 patients recently encountered at our institution as well as 13 additional cases identified in the recent literature. These tumors included 2 insulin-producing ovarian carcinoids, 1 ACTH-producing pituitary adenoma within a benign ovarian cystic teratoma, 2 cortisol-producing ovarian neoplasms, 8 gastrin-producing ovarian cystadenomata or cystadenocarcinomata, and 3 thyroxine-producing ovarian strumal carcinoids. All patients presented with syndromes of hormone excess. Only 62% of all tumors were localized preoperatively. Following ovarian resection, 87% of patients remained disease-free with a median follow-up period of 1.5 years. In addition to ovariectomy, 8 additional unnecessary ablative procedures were performed in 7 patients. These included distal pancreatectomy, pancreaticoduodenectomy, adrenalectomy, total gastrectomy, selective vagotomy, and subtotal thyroidectomy. Failure to localize the ovarian neoplasm preoperatively was associated with a significantly higher risk of subsequent unnecessary ablative procedures. Because of the potential for the ovary to act as a source of aberrant hormone secretion, we recommend complete preoperative evaluation of the pelvis in female patients presenting with nonlocalizable endocrine tumors.

Original languageEnglish (US)
Pages (from-to)335-340
Number of pages6
JournalWorld Journal of Surgery
Volume14
Issue number3
DOIs
StatePublished - May 1990
Externally publishedYes

Fingerprint

Ovarian Neoplasms
Hormones
Unnecessary Procedures
Carcinoid Tumor
Neoplasms
Therapeutics
ACTH-Secreting Pituitary Adenoma
Ectopic Hormones
Cystadenocarcinoma
Cystadenoma
Pancreatectomy
Pancreaticoduodenectomy
Vagotomy
Adrenalectomy
Teratoma
Thyroidectomy
Gastrins
Ovariectomy
Gastrectomy
Pelvis

ASJC Scopus subject areas

  • Surgery

Cite this

Leach, S. D., LaMorte, A. I., True, L. D., Flynn, S. D., Schwartz, P. E., Cahow, C. E., & Kinder, B. K. (1990). Aberrant hormone production from ovarian neoplasms: Strategies for diagnosis and therapy. World Journal of Surgery, 14(3), 335-340. https://doi.org/10.1007/BF01658520

Aberrant hormone production from ovarian neoplasms : Strategies for diagnosis and therapy. / Leach, Steven D.; LaMorte, Annette I.; True, Lawrence D.; Flynn, Stuart D; Schwartz, Peter E.; Cahow, C. Elton; Kinder, Barbara K.

In: World Journal of Surgery, Vol. 14, No. 3, 05.1990, p. 335-340.

Research output: Contribution to journalArticle

Leach, SD, LaMorte, AI, True, LD, Flynn, SD, Schwartz, PE, Cahow, CE & Kinder, BK 1990, 'Aberrant hormone production from ovarian neoplasms: Strategies for diagnosis and therapy', World Journal of Surgery, vol. 14, no. 3, pp. 335-340. https://doi.org/10.1007/BF01658520
Leach, Steven D. ; LaMorte, Annette I. ; True, Lawrence D. ; Flynn, Stuart D ; Schwartz, Peter E. ; Cahow, C. Elton ; Kinder, Barbara K. / Aberrant hormone production from ovarian neoplasms : Strategies for diagnosis and therapy. In: World Journal of Surgery. 1990 ; Vol. 14, No. 3. pp. 335-340.
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