Abnormal goblet cell glycoconjugates in rectal biopsies associated with an increased risk of neoplasia in patients with ulcerative colitis

Early results of a prospective study

C. R. Boland, Michael P Lance, B. Levin, R. H. Riddell, Y. S. Kim

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

A group of 18 patients with stable ulcerative colitis involving the entire colon for at least eight years was subjected to a biopsy of normal appearing rectal mucosa and followed prospectively over four years for the development of either dysplasia or cancer. Goblet cell glycoconjugate structure was examined in the rectal biopsies using fluorescein conjugated lectins. At the beginning of the study, 13 of the 18 patients had abnormalities of goblet cell muciri or cytoplasmic glycoconjugates in the rectal biopsies. Dysplasia subsequently developed in six and carcinoma in one of these patients. Among the five patients with normal lectin binding studies in the initial rectal biopsies, colonic dysplasia has subsequently developed in one. The abnormalities seen in the rectal goblet cells resembled in part those previously seen in immature and neoplastic colonic cells. The dysplastic tissues all contained the form of mucin which has been found in other neoplastic colonic tissues. This preliminary report after four years of prospective study suggests that abnormalities of glycoconjugate structure may be associated with, and may precede, neoplastic events in the setting of chronic ulcerative colitis.

Original languageEnglish (US)
Pages (from-to)1364-1371
Number of pages8
JournalGut
Volume25
Issue number12
DOIs
StatePublished - 1984
Externally publishedYes

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Glycoconjugates
Goblet Cells
Ulcerative Colitis
Prospective Studies
Biopsy
Lectins
Neoplasms
Mucins
Fluorescein
Colon
Mucous Membrane
Carcinoma

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Gastroenterology

Cite this

Abnormal goblet cell glycoconjugates in rectal biopsies associated with an increased risk of neoplasia in patients with ulcerative colitis : Early results of a prospective study. / Boland, C. R.; Lance, Michael P; Levin, B.; Riddell, R. H.; Kim, Y. S.

In: Gut, Vol. 25, No. 12, 1984, p. 1364-1371.

Research output: Contribution to journalArticle

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